Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

被引：31

作者：

Garner, Evan F. ^{[1
]}

Beierle, Elizabeth A. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Surg, Div Pediat Surg, Birmingham, AL 35233 USA

来源：

CANCERS | 2016年 / 8卷 / 01期

关键词：

neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia; BONE-MARROW METASTASES; HIGH-RISK NEUROBLASTOMA; SIDE POPULATION CELLS; INITIATING CELLS; ALDEHYDE DEHYDROGENASE; INFLAMMATORY CELLS; PERIVASCULAR NICHE; CXCR4; EXPRESSION; NKT CELLS; PATHWAY;

D O I：

10.3390/cancers8010005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.

引用

页数：13