Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

被引：31
|
作者：
Garner, Evan F. [1 ]
Beierle, Elizabeth A. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Surg, Div Pediat Surg, Birmingham, AL 35233 USA
来源：
CANCERS | 2016年 / 8卷 / 01期
关键词：
neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia; BONE-MARROW METASTASES; HIGH-RISK NEUROBLASTOMA; SIDE POPULATION CELLS; INITIATING CELLS; ALDEHYDE DEHYDROGENASE; INFLAMMATORY CELLS; PERIVASCULAR NICHE; CXCR4; EXPRESSION; NKT CELLS; PATHWAY;
D O I：
10.3390/cancers8010005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
引用
收藏
页数：13
相关论文
共 50 条
  • [31] Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review
    Dzobo, Kevin
    Senthebane, Dimakatso Alice
    Ganz, Chelene
    Thomford, Nicholas Ekow
    Wonkam, Ambroise
    Dandara, Collet
    CELLS, 2020, 9 (08) : 1 - 38
  • [32] Mesenchymal Stem Cells in the Tumor Microenvironment
    Atiya, Huda
    Frisbie, Leonard
    Pressimone, Catherine
    Coffman, Lan
    TUMOR MICROENVIRONMENT: NON-HEMATOPOIETIC CELLS, 2020, 1234 : 31 - 42
  • [33] Cancer Stem Cells and Immunosuppressive Microenvironment in Glioma
    Ma, Qianquan
    Long, Wenyong
    Xing, Changsheng
    Chu, Junjun
    Luo, Mei
    Wang, Helen Y.
    Liu, Qing
    Wang, Rong-Fu
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [34] The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment
    Filatova, Alina
    Acker, Till
    Garvalov, Boyan K.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 1830 (02): : 2496 - 2508
  • [35] Leukemia Stem Cells Microenvironment
    Tabe, Yoko
    Konopleva, Marina
    STEM CELL MICROENVIRONMENTS AND BEYOND, 2017, 1041 : 19 - 32
  • [36] Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment
    Jahanafrooz, Zohreh
    Mosafer, Jaffar
    Akbari, Morteza
    Hashemzaei, Mahmoud
    Mokhtarzadeh, Ahad
    Baradaran, Behzad
    JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (05) : 4153 - 4166
  • [37] Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?
    Romano, Maurizio
    De Francesco, Francesco
    Gringeri, Enrico
    Giordano, Antonio
    Ferraro, Giuseppe A.
    Di Domenico, Marina
    Cillo, Umberto
    JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (04) : 768 - 776
  • [38] Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum
    Francisco Islas, Jose
    Quiroz-Reyes, Adriana G.
    Delgado-Gonzalez, Paulina
    Franco-Villarreal, Hector
    Luis Delgado-Gallegos, Juan
    Garza-Trevino, Elsa N.
    Gonzalez-Villarreal, Carlos A.
    CANCERS, 2022, 14 (16)
  • [39] Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment
    Pacifico, Francesco
    Leonardi, Antonio
    Crescenzi, Elvira
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
  • [40] Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma
    Burgos-Panadero, Rebeca
    Noguera, Inmaculada
    Canete, Adela
    Navarro, Samuel
    Noguera, Rosa
    BMC CANCER, 2019, 19 (1)
12345