Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants' Neutrophils - A Pilot Study

被引：8
作者：
Siawaya, Anicet Christel Maloupazoa [1 ,2 ]
Mveang-Nzoghe, Amandine [1 ,2 ]
Ndjindji, Ofilia Mvoundza [1 ,2 ]
Ndong, Armel Mintsa [3 ]
Essone, Paulin N. [1 ,2 ,4 ,5 ]
Siawaya, Joel Fleury Djoba [1 ,2 ]
机构：
[1] Lab Natl Sante Publ, Unite Rech, Libreville, Gabon
[2] Lab Natl Sante Publ, Unite Diagnost Specialises, Libreville, Gabon
[3] Lab Natl Sante Publ, Unite Virol, Libreville, Gabon
[4] Univ Cape Town, Div Immunol, Inst Infect Dis & Mol Med IDM, Fac Hlth Sci, Cape Town, South Africa
[5] Univ Cape Town, South African Med Res Council SAMRC Immunol Infec, Cape Town, South Africa
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
关键词：
HIV; neutrophils; reactive oxygen species; nitroblue tetrazolium; infants; SEVERE INFECTIONS; CHILD-MORTALITY; MOTHERS; REDUCTION; BORN; 1ST;
D O I：
10.3389/fimmu.2017.00262
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
a An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for the protection of infants against bacterial infections, no study has investigated their profile in HEU infants to date. In this study, we assessed the function of neutrophils in HEU infants using the nitroblue tetrazolium reduction test. Among 25 HEU infants, 9 (36%) showed a reduced ability of their neutrophils to produce reactive oxygen species upon stimulation with bacteria. No alteration of total neutrophil counts was noted in the blood of HEU infants indicating that the alteration observed in the 36% of HEU infants may only be functional. Conclusively, impaired neutrophil function could be a factor of vulnerability in HEU infants.
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页数：7
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