Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants' Neutrophils - A Pilot Study

被引：8
|
作者：
Siawaya, Anicet Christel Maloupazoa [1 ,2 ]
Mveang-Nzoghe, Amandine [1 ,2 ]
Ndjindji, Ofilia Mvoundza [1 ,2 ]
Ndong, Armel Mintsa [3 ]
Essone, Paulin N. [1 ,2 ,4 ,5 ]
Siawaya, Joel Fleury Djoba [1 ,2 ]
机构：
[1] Lab Natl Sante Publ, Unite Rech, Libreville, Gabon
[2] Lab Natl Sante Publ, Unite Diagnost Specialises, Libreville, Gabon
[3] Lab Natl Sante Publ, Unite Virol, Libreville, Gabon
[4] Univ Cape Town, Div Immunol, Inst Infect Dis & Mol Med IDM, Fac Hlth Sci, Cape Town, South Africa
[5] Univ Cape Town, South African Med Res Council SAMRC Immunol Infec, Cape Town, South Africa
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
关键词：
HIV; neutrophils; reactive oxygen species; nitroblue tetrazolium; infants; SEVERE INFECTIONS; CHILD-MORTALITY; MOTHERS; REDUCTION; BORN; 1ST;
D O I：
10.3389/fimmu.2017.00262
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
a An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for the protection of infants against bacterial infections, no study has investigated their profile in HEU infants to date. In this study, we assessed the function of neutrophils in HEU infants using the nitroblue tetrazolium reduction test. Among 25 HEU infants, 9 (36%) showed a reduced ability of their neutrophils to produce reactive oxygen species upon stimulation with bacteria. No alteration of total neutrophil counts was noted in the blood of HEU infants indicating that the alteration observed in the 36% of HEU infants may only be functional. Conclusively, impaired neutrophil function could be a factor of vulnerability in HEU infants.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] HIV-exposed uninfected infants and children
    Slogrove, Amy L.
    Cotton, Mark F.
    JOURNAL OF VIRUS ERADICATION, 2017, 3 (04) : 258 - 258
  • [2] Impaired Humoral Response to Vaccines among HIV-Exposed Uninfected Infants
    Abramczuk, Beatriz Mariana
    Mazzola, Tais Nitsch
    Franco Moreno, Yara Maria
    Zorzeto, Tatiane Queiroz
    Quintilio, Wagner
    Wolf, Paulo Silva
    Blotta, Maria Heloisa
    Morcillo, Andre Moreno
    Nolasco da Silva, Marcos Tadeu
    dos Santos Vilela, Maria Marluce
    CLINICAL AND VACCINE IMMUNOLOGY, 2011, 18 (09) : 1406 - 1409
  • [3] HIV-exposed uninfected infants' immune defects: From pathogen sensing, oxidative burst to antigens responses
    Siawaya, Joel Fleury Djoba
    Siawaya, Anicet Christel Maloupazoa
    ISCIENCE, 2023, 26 (12)
  • [4] Delayed Seroreversion in HIV-exposed Uninfected Infants
    Chatpornvorarux, Sunsanee
    Maleesatharn, Alan
    Rungmaitree, Supattra
    Wittawatmongkol, Orasri
    Phongsamart, Wanatpreeya
    Lapphra, Keswadee
    Kongstan, Nantaka
    Khumcha, Benjawan
    Chokephaibulkit, Kulkanya
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2019, 38 (01) : 65 - 69
  • [5] Exposure of HIV-exposed uninfected infants to antiretrovirals
    Kazembe, Peter N.
    LANCET HIV, 2019, 6 (08): : E487 - E488
  • [6] The Immune System of HIV-Exposed Uninfected Infants
    Abu-Raya, Bahaa
    Kollmann, Tobias R.
    Marchant, Arnaud
    MacGillivray, Duncan M.
    FRONTIERS IN IMMUNOLOGY, 2016, 7
  • [7] Lymphocyte subsets in HIV-exposed uninfected infants and HIV-unexposed uninfected infants
    Huo, Yanling
    Patel, Kunjal
    Scott, Gwendolyn B.
    van Dyke, Russell B.
    Siberry, George K.
    Burchett, Sandra K.
    Shearer, William T.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (02) : 605 - +
  • [8] Neurodevelopmental status of HIV-exposed but uninfected children: A pilot study
    Springer, P.
    Laughton, B.
    Tomlinson, M.
    Harvey, J.
    Esser, M.
    SOUTH AFRICAN JOURNAL OF CHILD HEALTH, 2012, 6 (02) : 51 - 55
  • [9] Determinants of growth in HIV-exposed and HIV-uninfected infants in the Kabeho Study
    Lane, Charlotte E.
    Bobrow, Emily A.
    Ndatimana, Diuedonne
    Ndayisaba, Gilles F.
    Adair, Linda S.
    MATERNAL AND CHILD NUTRITION, 2019, 15 (03):
  • [10] Health outcomes of HIV-exposed uninfected African infants
    Kourtis, Athena P.
    Wiener, Jeffrey
    Kayira, Dumbani
    Chasela, Charles
    Ellington, Sascha R.
    Hyde, Lisa
    Hosseinipour, Mina
    van der Horst, Charles
    Jamieson, Denise J.
    AIDS, 2013, 27 (05) : 749 - 759
12345