Solvent-Free, Base-Free Microwave-Mediated Iridium-Catalyzed N-Alkylation of Amides with Alcohols

被引：13

作者：

Apsunde, Tushar D. ^{[1
]}

Trudell, Mark L. ^{[1
]}

机构：

[1] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 02期

关键词：

alcohol; alkylation; amide; iridium; BOND FORMATION; AMINES;

D O I：

10.1055/s-0033-1340142

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solvent-free, base-free microwave-mediated (Cp*IrCl2)(2)-catalyzed conditions for the N-alkylation of amides with alcohols have been developed. A series of primary and secondary alcohols have been shown to produce high yields of N-alkyl arylamides and N-alkyl alkylamides.

引用

页码：230 / 234

页数：5

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