Recognizing methylated histone variant H3.3 to prevent tumors

被引：4
作者：
Venkatesh, Swaminathan [1 ]
Workman, Jerry L. [1 ]
机构：
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
来源：
CELL RESEARCH | 2014年 / 24卷 / 06期
关键词：
TRANSCRIPTION; CHROMATIN; EXCHANGE;
D O I：
10.1038/cr.2014.50
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors. © 2014 IBCB, SIBS, CAS All rights reserved.
引用
收藏
页码：649 / 650
页数：2
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