Effects of the FITKids Randomized Controlled Trial on Executive Control and Brain Function

被引:384
作者
Hillman, Charles H. [1 ]
Pontifex, Matthew B. [2 ]
Castelli, Darla M. [3 ]
Khan, Naiman A. [1 ]
Raine, Lauren B. [1 ]
Scudder, Mark R. [1 ]
Drollette, Eric S. [1 ]
Moore, Robert D. [1 ]
Wu, Chien-Ting [4 ]
Kamijo, Keita [5 ]
机构
[1] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA
[2] Michigan State Univ, Dept Kinesiol, E Lansing, MI 48824 USA
[3] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA
[4] Schreiner Coll, Dept Exercise Sci, Kerrville, TX USA
[5] Waseda Univ, Sch Sport Sci, Tokorozawa, Saitama, Japan
基金
美国国家卫生研究院;
关键词
cognition; physical activity; aerobic fitness; randomized controlled trial; PHYSICAL-ACTIVITY; COGNITIVE CONTROL; AEROBIC FITNESS; OVERWEIGHT; CHILDREN; EXERCISE; SCHOOL; PERFORMANCE; ACTIVATION; CATCH;
D O I
10.1542/peds.2013-3219
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
OBJECTIVE: To assess the effect of a physical activity (PA) intervention on brain and behavioral indices of executive control in preadolescent children. METHODS: Two hundred twenty-one children (7-9 years) were randomly assigned to a 9-month afterschool PA program or a wait-list control. In addition to changes in fitness (maximal oxygen consumption), electrical activity in the brain (P3-ERP) and behavioral measures (accuracy, reaction time) of executive control were collected by using tasks that modulated attentional inhibition and cognitive flexibility. RESULTS: Fitness improved more among intervention participants from pretest to posttest compared with the wait-list control (1.3 mL/kg per minute, 95% confidence interval [CI]: 0.3 to 2.4; d = 0.34 for group difference in pre-to-post change score). Intervention participants exhibited greater improvements from pretest to posttest in inhibition (3.2%, 95% CI: 0.0 to 6.5; d = 0.27) and cognitive flexibility (4.8%, 95% CI: 1.1 to 8.4; d = 0.35 for group difference in pre-to-post change score) compared with control. Only the intervention group increased attentional resources from pretest to posttest during tasks requiring increased inhibition (1.4 mu V, 95% CI: 0.3 to 2.6; d = 0.34) and cognitive flexibility (1.5 mu V, 95% CI: 0.6 to 2.5; d = 0.43). Finally, improvements in brain function on the inhibition task (r = 0.22) and performance on the flexibility task correlated with intervention attendance (r = 0.24). CONCLUSIONS: The intervention enhanced cognitive performance and brain function during tasks requiring greater executive control. These findings demonstrate a causal effect of a PA program on executive control, and provide support for PA for improving childhood cognition and brain health.
引用
收藏
页码:E1063 / E1071
页数:9
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