Adversity in childhood is linked to mental and physical health throughout life

被引:440
作者
Nelson, Charles A. [1 ,2 ]
Scott, Richard David [1 ,2 ]
Bhutta, Zulfiqar A. [3 ,4 ]
Harris, Nadine Burke [5 ]
Danese, Andrea [6 ,7 ]
Samara, Muthanna [8 ]
机构
[1] Boston Childrens Hosp, Dept Pediat, Boston, MA 02215 USA
[2] Harvard Grad Sch Educ, Harvard Med Sch, Boston, MA 02115 USA
[3] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada
[4] Aga Khan Univ, Inst Global Hlth & Dev, Karachi, Pakistan
[5] State Calif, Sacramento, CA USA
[6] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
[7] South London & Maudsley NHS Fdn Trust, Natl & Specialist CAMHS Clin Trauma Anxiety & Dep, London, England
[8] Kingston Univ London, Dept Psychol, London, England
来源
BMJ-BRITISH MEDICAL JOURNAL | 2020年 / 371卷
关键词
NEURAL DEVELOPMENT DEPRIVATION; DIFFERENTIAL SUSCEPTIBILITY; BRAIN STRUCTURE; EXPERIENCES; STRESS; ASSOCIATION; CHILDREN; DISEASE; INSTITUTIONALIZATION; CONSEQUENCES;
D O I
10.1136/bmj.m3048
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prevalence of "toxic stress"and huge downstream consequences in disease, suffering, and financial costs make prevention and early intervention crucial, say Charles A Nelson and colleagues © 2020 The BMJ. All rights reserved.
引用
收藏
页数:9
相关论文
共 75 条
[1]   Adverse childhood experiences (ACEs), peer victimization, and substance use among adolescents [J].
Afifi, Tracie O. ;
Taillieu, Tamara ;
Salmon, Samantha ;
Davila, Isabel Garces ;
Stewart-Tufescu, Ashley ;
Fortier, Janique ;
Struck, Shannon ;
Asmundson, Gordon J. G. ;
Sareen, Jitender ;
MacMillan, Harriet L. .
CHILD ABUSE & NEGLECT, 2020, 106
[2]   The relationship between child abuse, parental divorce, and lifetime mental disorders and suicidality in a nationally representative adult sample [J].
Afifi, Trade O. ;
Boman, Jonathan ;
Fleisher, William ;
Sareen, Jitender .
CHILD ABUSE & NEGLECT, 2009, 33 (03) :139-147
[3]  
[Anonymous], 2019, VIBRANT HLTH KIDS AL, DOI DOI 10.17226/25466
[4]   Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment: A Systematic Review and Meta-analysis [J].
Baldwin, Jessie R. ;
Reuben, Aaron ;
Newbury, Joanne B. ;
Danese, Andrea .
JAMA PSYCHIATRY, 2019, 76 (06) :584-593
[5]   Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and meta-analysis [J].
Bellis, Mark A. ;
Hughes, Karen ;
Ford, Kat ;
Rodriguez, Gabriela Ramos ;
Sethi, Dinesh ;
Passmore, Jonathon .
LANCET PUBLIC HEALTH, 2019, 4 (10) :E517-E528
[6]   Beyond Diathesis Stress: Differential Susceptibility to Environmental Influences [J].
Belsky, Jay ;
Pluess, Michael .
PSYCHOLOGICAL BULLETIN, 2009, 135 (06) :885-908
[7]   Biological embedding of childhood adversity: from physiological mechanisms to clinical implications [J].
Berens, Anne E. ;
Jensen, Sarah K. G. ;
Nelson, Charles A., III .
BMC MEDICINE, 2017, 15
[8]   Early Adverse Experiences and the Developing Brain [J].
Bick, Johanna ;
Nelson, Charles A. .
NEUROPSYCHOPHARMACOLOGY, 2016, 41 (01) :177-196
[9]   Effect of Early Institutionalization and Foster Care on Long-term White Matter Development A Randomized Clinical Trial [J].
Bick, Johanna ;
Zhu, Tong ;
Stamoulis, Catherine ;
Fox, Nathan A. ;
Zeanah, Charles ;
Nelson, Charles A. .
JAMA PEDIATRICS, 2015, 169 (03) :211-219
[10]   Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection [J].
Blackburn, Elizabeth H. ;
Epel, Elissa S. ;
Lin, Jue .
SCIENCE, 2015, 350 (6265) :1193-1198