Harnessing the Versatility of Optical Biosensors for Target-Based Small-Molecule Drug Discovery

被引：27

作者：

Kaminski, Tim ^{[1
]}

Gunnarsson, Anders ^{[1
]}

Geschwindner, Stefan ^{[1
]}

机构：

[1] AstraZeneca, Discovery Sci Innovat Med & Early Dev Biotech Uni, Pepparedsleden 1, S-43183 Molndal, Sweden

来源：

ACS SENSORS | 2017年 / 2卷 / 01期

关键词：

drug discovery; small molecule; kinetics; single molecule; surface plasmon resonance; waveguide-grating; biolayer interferometry; ASSAYS; ADVANTAGES; IMPACT;

D O I：

10.1021/acssensors.6b00735

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optical biosensors entered target-based small-molecule drug discovery more than two decades ago and have since transformed into a value-adding component in the decision-making process. Here, we briefly highlight the major application areas of optical biosensors and focus on desirable profiles of such platforms in order to ensure their effective use in small molecule drug discovery. Furthermore, we will emphasize current technology-based constraints and discuss experimental strategies to address these limitations as well as provide a view of necessary technology improvements for next generation platforms.

引用

页码：10 / 15

页数：6

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