Nutritional components regulate the gut immune system and its association with intestinal immune disease development

被引：15

作者：

Lamichhane, Aayam ^{[1
,2
,4
,5
]}

Kiyono, Hiroshi ^{[1
,2
,3
,4
]}

Kunisawa, Jun ^{[1
,2
,3
,5
,6
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo, Japan

[2] Japan Sci & Technol Agcy, CREST, Tokyo, Japan

[3] Univ Tokyo, Inst Med Sci, Int Res & Dev Ctr Mucosal Vaccines, Tokyo, Japan

[4] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Chiba, Japan

[5] Osaka Univ, Natl Inst Biomed Innovat, Lab Vaccine Mat, Osaka, Japan

[6] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 28卷

关键词：

allergy; intestinal immunity; lipid; nucleotide; vitamin; SPHINGOSINE; 1-PHOSPHATE; LYMPHOCYTE EGRESS; DENDRITIC CELLS; T-CELLS; B-CELLS; TRAFFICKING; FTY720; INFLAMMATION; FOLATE; TH2;

D O I：

10.1111/jgh.12259

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut is equipped with a unique immune system for maintaining immunological homeostasis, and its functional immune disruption can result in the development of immune diseases such as food allergy and intestinal inflammation. Accumulating evidence has demonstrated that nutritional components play an important role in the regulation of gut immune responses and also in the development of intestinal immune diseases. In this review, we focus on the immunological functions of lipids, vitamins, and nucleotides in the regulation of the intestinal immune system and as potential targets for the control of intestinal immune diseases.

引用

页码：18 / 24

页数：7

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