Platelet and neutrophil to lymphocyte ratios predict survival in patients with resectable colorectal liver metastases

被引：17
作者：
Erstad, Derek J. [1 ]
Taylor, Martin S. [2 ]
Qadan, Motaz [1 ]
Axtell, Andrea L. [1 ,3 ]
Fuchs, Bryan C. [1 ]
Berger, David L. [1 ]
Clancy, Thomas E. [4 ]
Tanabe, Kenneth K. [1 ]
Chang, David C. [1 ,3 ]
Ferrone, Cristina R. [1 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Boston, MA 02115 USA
[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA
[3] Harvard Med Sch, Massachusetts Gen Hosp, Codman Ctr Clin Effectiveness Surg, Boston, MA 02115 USA
[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA
来源：
AMERICAN JOURNAL OF SURGERY | 2020年 / 220卷 / 06期
关键词：
Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Colorectal; Liver metastasis; Hepatectomy; Overall survival; Prognosis; LONG-TERM SURVIVAL; HEPATIC RESECTION; CANCER; TUMOR; BIOLOGY;
D O I：
10.1016/j.amjsurg.2020.05.003
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: The prognostic significance of the platelet (PLR) and neutrophil (NLR) to lymphocyte ratios for patients with resectable colorectal cancer liver metastases (CLM) was evaluated. Methods: Clinicopathologic data from patients who underwent hepatectomy for CLM at two tertiary care hospitals between 1995 and 2017 were collected. Blood counts were evaluated for prognostic significance. Results: 151 patients met inclusion criteria. The median age was 58 years, 44% were female, and 58% had synchronous metastases. Median number of liver metastases was 2, and 59% of patients underwent lobectomy or extended lobectomy. On multivariable analysis, NLR >5 (HR 2.46 [1.08-5.60 CI], p = 0.032), PLR > 220 (HR 2.10 [1.04-4.23 CI], p = 0.037), and greater than 2 liver metastases (HR 2.41 [1.06-5.45 CI], p = 0.035) were associated with reduced overall survival. Conclusions: PLR > 220 and NLR > 5 may have utility as preoperative prognostic markers for overall survival in patients with resectable CLM. (c) 2020 Elsevier Inc. All rights reserved.
引用
收藏
页码：1579 / 1585
页数：7
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