Platelet and neutrophil to lymphocyte ratios predict survival in patients with resectable colorectal liver metastases

被引：20

作者：

Erstad, Derek J. ^{[1
]}

Taylor, Martin S. ^{[2
]}

Qadan, Motaz ^{[1
]}

Axtell, Andrea L. ^{[1
,3
]}

Fuchs, Bryan C. ^{[1
]}

Berger, David L. ^{[1
]}

Clancy, Thomas E. ^{[4
]}

Tanabe, Kenneth K. ^{[1
]}

Chang, David C. ^{[1
,3
]}

Ferrone, Cristina R. ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Boston, MA 02115 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Codman Ctr Clin Effectiveness Surg, Boston, MA 02115 USA

[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2020年 / 220卷 / 06期

关键词：

Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio; Colorectal; Liver metastasis; Hepatectomy; Overall survival; Prognosis; LONG-TERM SURVIVAL; HEPATIC RESECTION; CANCER; TUMOR; BIOLOGY;

D O I：

10.1016/j.amjsurg.2020.05.003

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The prognostic significance of the platelet (PLR) and neutrophil (NLR) to lymphocyte ratios for patients with resectable colorectal cancer liver metastases (CLM) was evaluated. Methods: Clinicopathologic data from patients who underwent hepatectomy for CLM at two tertiary care hospitals between 1995 and 2017 were collected. Blood counts were evaluated for prognostic significance. Results: 151 patients met inclusion criteria. The median age was 58 years, 44% were female, and 58% had synchronous metastases. Median number of liver metastases was 2, and 59% of patients underwent lobectomy or extended lobectomy. On multivariable analysis, NLR >5 (HR 2.46 [1.08-5.60 CI], p = 0.032), PLR > 220 (HR 2.10 [1.04-4.23 CI], p = 0.037), and greater than 2 liver metastases (HR 2.41 [1.06-5.45 CI], p = 0.035) were associated with reduced overall survival. Conclusions: PLR > 220 and NLR > 5 may have utility as preoperative prognostic markers for overall survival in patients with resectable CLM. (c) 2020 Elsevier Inc. All rights reserved.

引用

页码：1579 / 1585

页数：7

共 28 条

[1] A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].

CHARLSON, ME ;

POMPEI, P ;

ALES, KL ;

MACKENZIE, CR .

JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383

[2] Elements of cancer immunity and the cancer-immune set point [J].

Chen, Daniel S. ;

Mellman, Ira .

NATURE, 2017, 541 (7637) :321-330

[3]

Chen N, 2017, ONCOTARGET, V8, P32356, DOI 10.18632/oncotarget.16020

[4] Trends in long-term survival following liver resection for hepatic colorectal metastases [J].

Choti, MA ;

Sitzmann, JV ;

Tiburi, MF ;

Sumetchotimetha, W ;

Rangsin, R ;

Schulick, RD ;

Lillemoe, KD ;

Yeo, CJ ;

Cameron, JL .

ANNALS OF SURGERY, 2002, 235 (06) :759-765

[5] Chemotherapy-induced neutropenia - Risks, consequences, and new directions for its management [J].

Crawford, J ;

Dale, DC ;

Lyman, GH .

CANCER, 2004, 100 (02) :228-237

[6] Rates and Patterns of Recurrence Following Curative Intent Surgery for Colorectal Liver Metastasis An International Multi-Institutional Analysis of 1669 Patients [J].

de Jong, Mechteld C. ;

Pulitano, Carlo ;

Ribero, Dario ;

Strub, Jennifer ;

Mentha, Gilles ;

Schulick, Richard D. ;

Choti, Michael A. ;

Aldrighetti, Luca ;

Capussotti, Lorenzo ;

Pawlik, Timothy M. .

ANNALS OF SURGERY, 2009, 250 (03) :440-448

[7] The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis [J].

Dolan, Ross D. ;

Lim, Jason ;

McSorley, Stephen T. ;

Horgan, Paul G. ;

McMillan, Donald C. .

SCIENTIFIC REPORTS, 2017, 7

[8] Inflammation and cancer: What a surgical oncologist should know [J].

Dupre, Aurelien ;

Malik, Hassan Z. .

EJSO, 2018, 44 (05) :566-570

[9] Contribution of platelets to tumour metastasis [J].

Gay, Laurie J. ;

Felding-Habermann, Brunhilde .

NATURE REVIEWS CANCER, 2011, 11 (02) :123-134

[10] Interaction of tumour biology and tumour burden in determining outcome after hepatic resection for colorectal metastases [J].

Gomez, Dhanny ;

Morris-Stiff, Gareth ;

Toogood, Giles John ;

Lodge, J. Peter A. ;

Prasad, K. Raj .

HPB, 2010, 12 (02) :84-93

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