Metabolic Syndrome and cognitive decline in the elderly: A systematic review

被引：95
作者：
Assuncao, Naima [1 ,2 ]
Sudo, Felipe Kenji [1 ,3 ]
Drummond, Claudia [1 ,4 ]
de Felice, Fernanda Guarino [2 ,5 ]
Mattos, Paulo [1 ,2 ,6 ]
机构：
[1] DOr Inst Res & Educ, Memory Clin, Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Inst Biomed Sci, Morphol Sci Program, Rio De Janeiro, Brazil
[3] Pontifical Catholic Univ Rio de Janeiro, Dept Psychol, Rio De Janeiro, Brazil
[4] Univ Fed Rio de Janeiro, Dept Speech & Hearing Pathol, Rio De Janeiro, Brazil
[5] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil
[6] Univ Fed Rio de Janeiro, Inst Psychiat, Dept Psychiat & Forens Med, Rio De Janeiro, Brazil
来源：
PLOS ONE | 2018年 / 13卷 / 03期
关键词：
CLOCK-DRAWING TEST; BODY-MASS INDEX; INSULIN-RESISTANCE; LONGITUDINAL CHANGES; ALZHEIMERS-DISEASE; OLDEST-OLD; FOLLOW-UP; IMPAIRMENT; RISK; HYPERTENSION;
D O I：
10.1371/journal.pone.0194990
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background Metabolic Syndrome (MetS) refers to a cluster of metabolic disturbances which is associated with increased risk for vascular and degenerative conditions in general population. Although the relationship between vascular risk factors and dementia is undisputable, additional hazard for cognitive decline in older population with concurrent metabolic disorders still waits to be demonstrated. The present review aims to analyze data on MetS and risk for cognitive decline in elderly persons. Methods Database searches were performed in Medline, ISI and Psycl NFO for articles assessing cognitive performances of older subjects with MetS. Results Of a total of 505 studies, 25 were selected for the review. Risk of selection biases was identified in all the studies. Although all articles followed recognized diagnostic recommendations for MetS, minor criteria modifications were detected in most of them. Hyperglycemia was consistently associated with impaired cognitive performances in older individuals, but the role of MetS for cognitive decline and for the onset of dementia showed heterogeneous results. Discussion Current available data in the literature concerning the impact of MetS on the cognition of older population is inconclusive and based on inconsistent evidence. Differential effects of individual MetS components and factors associated with the age of the sample may have accounted for divergent findings among articles, but larger and higher quality studies in this field are still needed.
引用
收藏
页数：16
相关论文
共 62 条
[1]  
Alberti K.G., 2016, DIABETIC MED, V23, P469
[2]  
[Anonymous], 2005, Nihon Naika Gakkai Zasshi, V94, P794
[3]   Observational Studies: Getting Clear about Transparency [J].
Connell, Laureen ;
MacDonald, Rhona ;
McBride, Thomas ;
Peiperl, Larry ;
Ross, Amy ;
Simpson, Paul ;
Winker, Maggie .
PLOS MEDICINE, 2014, 11 (08)
[4]  
Balkau B, 2002, DIABETES METAB, V28, P364
[5]   The metabolic syndrome is associated with decelerated cognitive decline in the oldest old [J].
van den Berg, E. ;
Biessels, G. J. ;
de Craen, A. J. M. ;
Gussekloo, J. ;
Westendorp, R. G. J. .
NEUROLOGY, 2007, 69 (10) :979-985
[6]   The relationship between body mass index and waist circumference: implications for estimates of the population prevalence of overweight [J].
Booth, ML ;
Hunter, C ;
Gore, CJ ;
Bauman, A ;
Owen, N .
INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (08) :1058-1061
[7]   Nutritional predictors of cognitive impairment severity in demented elderly patients: The key role of BMI [J].
Coin, A. ;
Veronese, N. ;
De Rui, M. ;
Mosele, M. ;
Bolzetta, F. ;
Girardi, A. ;
Manzato, E. ;
Sergi, G. .
JOURNAL OF NUTRITION HEALTH & AGING, 2012, 16 (06) :553-556
[8]   Age of onset of hypertension and risk of dementia in the oldest-old: The 90+Study [J].
Corrada, Maria M. ;
Hayden, Kathleen M. ;
Paganini-Hill, Annlia ;
Bullain, Szofia S. ;
DeMoss, Jaime ;
Aguirre, Colette ;
Brookmeyer, Ron ;
Kawas, Claudia H. .
ALZHEIMERS & DEMENTIA, 2017, 13 (02) :103-110
[9]   The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group [J].
Costa, Alberto ;
Bak, Thomas ;
Caffarra, Paolo ;
Caltagirone, Carlo ;
Ceccaldi, Mathieu ;
Collette, Fabienne ;
Crutch, Sebastian ;
Della Sala, Sergio ;
Demonet, Jean Francois ;
Dubois, Bruno ;
Duzel, Emrah ;
Nestor, Peter ;
Papageorgiou, Sokratis G. ;
Salmon, Eric ;
Sikkes, Sietske ;
Tiraboschi, Pietro ;
van der Flier, Wiesje M. ;
Visser, Pieter Jelle ;
Cappa, Stefano F. .
ALZHEIMERS RESEARCH & THERAPY, 2017, 9
[10]   Improving clinical cognitive testing Report of the AAN Behavioral Neurology Section Workgroup [J].
Daffner, Kirk R. ;
Gale, Seth A. ;
Barrett, A. M. ;
Boeve, Bradley F. ;
Chatterjee, Anjan ;
Coslett, H. Branch ;
D'Esposito, Mark ;
Finney, Glen R. ;
Gitelman, Darren R. ;
Hart, John J., Jr. ;
Lerner, Alan J. ;
Meador, Kimford J. ;
Pietras, Alison C. ;
Voeller, Kytja S. ;
Kaufer, Daniel I. .
NEUROLOGY, 2015, 85 (10) :910-918
1234567