Risk factors for an early dialysis start in patients with diabetic nephropathy end-stage renal disease

被引:7
作者
Mizuno, Tomohiro [1 ,2 ]
Hayashi, Takahiro [3 ]
Kato, Rina [1 ]
Noguchi, Ayaka [1 ]
Hayashi, Hiroki [2 ]
Yuzawa, Yukio [2 ]
Yamada, Shigeki [3 ]
Nagamatsu, Tadashi [1 ]
机构
[1] Meijo Univ, Fac Pharm, Dept Analyt Pharmacol, Nagoya, Aichi 4688503, Japan
[2] Fujita Hlth Univ, Sch Med, Dept Nephrol, Toyoake, Aichi 47011, Japan
[3] Fujita Hlth Univ, Sch Med, Dept Clin Pharm, Toyoake, Aichi 47011, Japan
来源
THERAPEUTICS AND CLINICAL RISK MANAGEMENT | 2014年 / 10卷
基金
日本学术振兴会;
关键词
early dialysis; diabetes mellitus; nephropathy; elderly patients; estimated glomerular filtration rate; EARLY INITIATION; COMORBIDITY;
D O I
10.2147/TCRM.S57853
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background: Patients with end-stage renal disease (ESRD) have symptoms related to severe anemia, edema, and heart failure. Although dialysis improves ESRD syndromes, the optimum timing for initiation of dialysis is unclear. Recent observational studies have suggested that early commencement of dialysis can be harmful. Given that early dialysis may increase the risk of death, avoiding an early start to dialysis is recommended. Patients with diabetic nephropathy (DN) may have risk factors for early dialysis. However, the risk factors for early dialysis are unclear in ESRD patients with DN. The aim of this study was to elucidate the risk factors for early initiation of dialysis in patients with DN and ESRD. Methods: From April 2009 to December 2012, we identified Japanese DN patients with an estimated glomerular filtration rate of less than 15 mL/minute/1.73 m(2). The patients were divided into late or early dialysis groups based on the timing of start of dialysis. Results: We evaluated 52 patients who commenced dialysis during the observation period, including 33 in the late dialysis group and 19 in the early dialysis group. There was a significant association between early dialysis and age >= 65 years (odds ratio 4.59). The incidence of pneumonia before starting dialysis was significantly higher in elderly patients than in nonelderly patients. Conclusion: Our findings suggest that elderly patients with DN and ESRD have an increased risk of early initiation of dialysis, and occurrence of pneumonia is also associated with early dialysis. To avoid early commencement of dialysis, booster pneumococcal vaccination could be useful in elderly DN patients with ESRD.
引用
收藏
页码:73 / 76
页数:4
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