The GDNF family: Signalling, biological functions and therapeutic value

被引：1460

作者：

Airaksinen, MS ^{[1
]}

Saarma, M ^{[1
]}

机构：

[1] Univ Helsinki, Viikki Bioctr, Inst Biotechnol, Programme Mol Neurobiol, FIN-00014 Helsinki, Finland

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 05期

基金：

芬兰科学院;

关键词：

D O I：

10.1038/nrn812

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families - comprising neurotrophins and GDNF-family ligands (GFLs), respectively - are crucial for the development and maintenance of distinct sets of central and peripheral neurons. Knockout studies in the mouse have revealed that members of these two families might collaborate or act sequentially in a given neuron. Although neurotrophins and GFLs activate common intracellular signalling pathways through their receptor tyrosine kinases, several clear differences exist between these families of trophic factors.

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页码：383 / 394

页数：12

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