Enabling the Use of Heterocyclic Arynes in Chemical Synthesis

被引：89

作者：

Goetz, Adam E. ^{[1
]}

Garg, Neil K. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 03期

关键词：

DIELS-ALDER REACTIONS; SELECTIVE NUCLEOPHILIC-ADDITION; NICKEL-CATALYZED AMINATION; 1,3-DIPOLAR CYCLOADDITIONS; HETARYNE CYCLOADDITIONS; 2-SUBSTITUTED FURANS; ALKALOID ELLIPTICINE; ENE REACTION; ARYL ETHERS; REGIOSELECTIVITY;

D O I：

10.1021/jo402723e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heterocyclic arynes have long been targeted as potential tools for the synthesis of substituted heterocycles. Recent advances have led to an improved understanding of the factors that determine regioselectivity in reactions of these strained intermediates and, in turn, the aryne distortion model. This paper highlights the use of this predictive model to enable the use of heterocyclic arynes, such as indolynes and pyridynes, in chemical synthesis.

引用

页码：846 / 851

页数：6

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