Facets of Small RNA-Mediated Regulation in Legionella pneumophila

被引：3

作者：

Trigui, Hana ^{[1
]}

Mendis, Nilmini ^{[1
]}

Li, Laam ^{[1
]}

Saad, Mariam ^{[1
]}

Faucher, Sebastien P. ^{[1
]}

机构：

[1] McGill Univ, Fac Agr & Environm Sci, Dept Nat Resource Sci, Ste Anne De Bellevue, PQ H9X 3V9, Canada

来源：

MOLECULAR MECHANISMS IN LEGIONELLA PATHOGENESIS | 2014年 / 376卷

关键词：

GENERAL STRESS-RESPONSE; IV SECRETION SYSTEM; SM-LIKE PROTEIN; RYHB SMALL RNA; MESSENGER-RNA; ESCHERICHIA-COLI; LEGIONNAIRES-DISEASE; 6S RNA; INTRACELLULAR INFECTION; TRANSMISSION PHENOTYPE;

D O I：

10.1007/82_2013_347

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Legionella pneumophila is a water-borne pathogen that causes a severe lung infection in humans. It is able to replicate inside amoeba in the water environment, and inside lung macrophages in humans. Efficient regulation of gene expression is critical for responding to the conditions that L. pneumophila encounters and for intracellular multiplication in host cells. In the last two decades, many reports have contributed to our understanding of the critical importance of small regulatory RNAs (sRNAs) in the regulatory network of bacterial species. This report presents the current state of knowledge about the sRNAs expressed by L. pneumophila and discusses a few regulatory pathways in which sRNAs should be involved in this pathogen.

引用

页码：53 / 80

页数：28

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