Iriomoteolide-13a, a cytotoxic 22-membered macrolide from a marine dinoflagellate Amphidinium species

被引：20

作者：

Akakabe, Mai ^{[1
]}

Kumagai, Keiko ^{[1
]}

Tsuda, Masayuki ^{[1
]}

Konishi, Yuko ^{[1
]}

Tominaga, Akira ^{[2
,3
]}

Tsuda, Masashi ^{[4
]}

Fukushi, Eri ^{[5
]}

Kawabata, Jun ^{[5
]}

机构：

[1] Kochi Univ, Ctr Sci Res, Kochi 7838505, Japan

[2] Kochi Univ, Grad Sch Kuroshio Sci, Kochi 7838505, Japan

[3] Kochi Univ, Kochi Med Sch, Kochi 7838505, Japan

[4] Kochi Univ, Ctr Adv Marine Core Res, Kochi 7838502, Japan

[5] Hokkaido Univ, Res Fac Agr, Sapporo, Hokkaido 0608589, Japan

来源：

TETRAHEDRON | 2014年 / 70卷 / 18期

基金：

日本学术振兴会;

关键词：

22-Membered macrolide; Dinoflagellate; Amphidinium; Cytotoxic activity; Hexahydrofuro[3,2-b]furan; BIOACTIVE MACROLIDES; SP-NOV; DINOPHYCEAE;

D O I：

10.1016/j.tet.2014.03.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iriomoteolide-13a (1) has been isolated from a benthic dinoflagellate Amphidinium sp. (strain KCA09053) as a new 22-membered macrolide containing one hexahydrofuro[3,2-b]furan ring, one tetrahydropyran ring, two tetrahydrofuran rings, three one-carbon branches, and three hydroxyl groups including two hemiketals. The structure of 1 was assigned on the basis of a detailed 2D NMR analysis. Compound 1 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells (IC50: 0.5 mu g/mL). (C) 2014 Elsevier Ltd. All rights reserved.

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页码：2962 / 2965

页数：4

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