Synthesis of dihydropyrano[4,3-b]pyranes via a multi-component reaction catalyzed by lipase

被引：15

作者：

Chen, Xiao ^{[1
]}

Zhang, Weian ^{[1
]}

Yang, Fengjuan ^{[1
]}

Guo, Chao ^{[1
]}

Zhao, Ziyuan ^{[1
]}

Ji, Di ^{[3
]}

Zhou, Fan ^{[1
]}

Wang, Zhi ^{[1
]}

Zhaob, Rui ^{[2
]}

Wang, Lei ^{[1
]}

机构：

[1] Jilin Univ, Sch Life Sci, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun, Peoples R China

[2] Jilin Univ, China Japan Union Hosp, Changchun, Peoples R China

[3] First Middle Sch Changchun City, Changchun, Peoples R China

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2017年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Lipase; promiscuity; multi-component reaction; dihydropyrano[4,3-b]pyranes; AQUEOUS-MEDIA; 2-AMINO-2-CHROMENES; DERIVATIVES; WATER;

D O I：

10.1080/17518253.2017.1285442

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A green method for the synthesis of dihydropyrano[4,3-b]pyranes via a three-component reaction catalyzed by lipase is reported firstly. Under the optimal conditions, high yields of dihydropyrano [4,3-b] pyranes (80.8-96.8%) could be obtained in this enzymatic reaction. This study not only expands the application of lipase in organic synthesis, but also provides an alternative efficient method for the synthesis of dihydropyrano[4,3-b]pyranes. [GRAPHICS] .

引用

页码：54 / 58

页数：5

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