Immune cell analysis of pilocytic astrocytomas reveals sexually dimorphic brain region-specific differences in T-cell content

被引：9

作者：

Chen, Jie ^{[1
,2
]}

Sinha, Namita ^{[1
,3
]}

Cobb, Olivia ^{[4
]}

Liu, Collin ^{[5
]}

Ersen, Ayca ^{[6
]}

Phillips, Joanna J. ^{[7
,8
]}

Tihan, Tarik ^{[7
]}

Gutmann, David H. ^{[4
]}

Dahiya, Sonika ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Neuropathol, 660 South Euclid Ave,Campus Box 8118, St Louis, MO 63110 USA

[2] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

[3] Univ Manitoba, Hlth Sci Ctr, Dept Pathol, Winnipeg, MB, Canada

[4] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[5] Univ Nebraska Med Ctr, Dept Neurol Surg, Omaha, NE USA

[6] Dokuz Eylul Univ, Fac Med, Dept Pathol, Izmir, Turkey

[7] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[8] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA

来源：

NEURO-ONCOLOGY ADVANCES | 2021年 / 3卷 / 01期

关键词：

EXPRESSION;

D O I：

10.1093/noajnl/vdab068

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pilocytic astrocytoma (PA) is the most common glioma in children, with an excellent overall survival following surgical resection; however, a small subset of tumors recur, especially following incomplete resection. Since PAs contain a large number of non-neoplastic cells, immunomodulatory therapies have been proposed, particularly in light of results using experimental mouse models of low-grade glioma (LGG), where microglia and T cells were found to be critical non-neoplastic drivers of tumor formation and growth.(1)

引用

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