Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C-elegans

被引：139
|
作者：
Detwiler, MR [1 ]
Reuben, M [1 ]
Li, XM [1 ]
Rogers, R [1 ]
Lin, RL [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
来源：
DEVELOPMENTAL CELL | 2001年 / 1卷 / 02期
关键词：
D O I：
10.1016/S1534-5807(01)00026-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase 1. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.
引用
收藏
页码：187 / 199
页数：13
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