Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C-elegans

被引：139

作者：

Detwiler, MR ^{[1
]}

Reuben, M ^{[1
]}

Li, XM ^{[1
]}

Rogers, R ^{[1
]}

Lin, RL ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

来源：

DEVELOPMENTAL CELL | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(01)00026-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase 1. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.

引用

页码：187 / 199

页数：13

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