Enzalutamide, apalutamide, or darolutamide: are apples or bananas best for patients?

被引：23
作者：
Higano, Celestia [1 ,2 ]
机构：
[1] Univ Washington, Dept Med, Div Oncol, Seattle, WA 98195 USA
[2] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
来源：
NATURE REVIEWS UROLOGY | 2019年 / 16卷 / 06期
关键词：
RESISTANT PROSTATE-CANCER; METASTASIS-FREE SURVIVAL; MEN;
D O I：
10.1038/s41585-019-0186-2
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The PROSPER, SPARTAN, and ARAMIS trials demonstrated the efficacy of enzalutamide, apalutamide, and darolutamide, respectively, to extend metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer. However, questions remain regarding patient selection for these agents, particularly concerning adverse effects, patient PSA doubling time, and cost and formulary considerations.
引用
收藏
页码：335 / 336
页数：3
相关论文
共 9 条
[1]   Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer [J].
Fizazi, Karim ;
Shore, Neal ;
Tammela, Teuvo L. ;
Ulys, Albertas ;
Vjaters, Egils ;
Polyakov, Sergey ;
Jievaltas, Mindaugas ;
Luz, Murilo ;
Alekseev, Boris ;
Kuss, Iris ;
Kappeler, Christian ;
Snapir, Amir ;
Sarapohja, Toni ;
Smith, Matthew R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (13) :1235-1246
[2]   Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer [J].
Hussain, Maha ;
Fizazi, Karim ;
Saad, Fred ;
Rathenborg, Per ;
Shore, Neal ;
Ferreira, Ubirajara ;
Ivashchenko, Petro ;
Demirhan, Eren ;
Modelska, Katharina ;
Phung, De ;
Krivoshik, Andrew ;
Sternberg, Cora N. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2465-2474
[3]   Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies [J].
Moilanen, Anu-Maarit ;
Riikonen, Reetta ;
Oksala, Riikka ;
Ravanti, Laura ;
Aho, Eija ;
Wohlfahrt, Gerd ;
Nykanen, Pirjo S. ;
Tormakangas, Olli P. ;
Palvimo, Jorma J. ;
Kallio, Pekka J. .
SCIENTIFIC REPORTS, 2015, 5
[4]  
Ruiz Garcia P, 2016, ANN ONCOL S, V27, p738P
[5]   Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study [J].
Scher, Howard I. ;
Beer, Tomasz M. ;
Higano, Celestia S. ;
Anand, Aseem ;
Taplin, Mary-Ellen ;
Efstathiou, Eleni ;
Rathkopf, Dana ;
Shelkey, Julia ;
Yu, Evan Y. ;
Alumkal, Joshi ;
Hung, David ;
Hirmand, Mohammad ;
Seely, Lynn ;
Morris, Michael J. ;
Danila, Daniel C. ;
Humm, John ;
Larson, Steve ;
Fleisher, Martin ;
Sawyers, Charles L. .
LANCET, 2010, 375 (9724) :1437-1446
[6]   Seizure Rates in Enzalutamide-Treated Men With Metastatic Castration-Resistant Prostate Cancer and Risk of Seizure The UPWARD Study [J].
Slovin, Susan ;
Clark, William ;
Carles, Joan ;
Krivoshik, Andrew ;
Park, Jung Wook ;
Wang, Fong ;
George, Daniel .
JAMA ONCOLOGY, 2018, 4 (05) :702-706
[7]   Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer [J].
Smith, Matthew R. ;
Saad, Fred ;
Chowdhury, Simon ;
Oudard, Stephane ;
Hadaschik, Boris A. ;
Graff, Julie N. ;
Olmos, David ;
Mainwaring, Paul N. ;
Lee, Ji Youl ;
Uemura, Hiroji ;
Lopez-Gitlitz, Angela ;
Trudel, Geralyn C. ;
Espina, Byron M. ;
Shu, Youyi ;
Park, Youn C. ;
Rackoff, Wayne R. ;
Yu, Margaret K. ;
Small, Eric J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (15) :1408-1418
[8]   Denosumab and Bone Metastasis-Free Survival in Men With Nonmetastatic Castration-Resistant Prostate Cancer: Exploratory Analyses by Baseline Prostate-Specific Antigen Doubling Time [J].
Smith, Matthew R. ;
Saad, Fred ;
Oudard, Stephane ;
Shore, Neal ;
Fizazi, Karim ;
Sieber, Paul ;
Tombal, Bertrand ;
Damiao, Ronaldo ;
Marx, Gavin ;
Miller, Kurt ;
Van Veldhuizen, Peter ;
Morote, Juan ;
Ye, Zhishen ;
Dansey, Roger ;
Goessl, Carsten .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (30) :3800-+
[9]   Adverse events of special interest assessed by review of safety data in enzalutamide castration-resistant prostate cancer (CRPC) trials. [J].
Tombal, Bertrand F. ;
Armstrong, Andrew J. ;
Barrus, Jeffrey Kent ;
Beer, Tomasz M. ;
Chowdhury, Simon ;
Evans, Christopher P. ;
Heidenreich, Axel ;
Higano, Celestia S. ;
Kamba, Tomomi ;
Lin, Ping ;
Nikolayeva, Natalia ;
Sugg, Jennifer ;
Steinberg, Joyce Leta ;
Taplin, Mary Ellen ;
Saad, Fred .
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (07)
1