Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2,-5,-6, and-11 and the Newly Characterized VIM-18)

被引：53

作者：

Castanheira, Mariana ^{[1
]}

Bell, Jan M. ^{[2
]}

Turnidge, John D. ^{[2
]}

Mathai, Dillip ^{[3
]}

Jones, Ronald N. ^{[1
,4
]}

机构：

[1] JMI Labs, N Liberty, IA 52317 USA

[2] Womens & Childrens Hosp, Adelaide, SA, Australia

[3] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India

[4] Tufts Univ, Sch Med, Boston, MA 02110 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 03期

关键词：

D O I：

10.1128/AAC.01011-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among 57 metallo-beta-lactamase (M beta L)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized bla(VIM) gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of bla(VIM-2)-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of bla(VIM) types and M beta L-carrying integrons.

引用

页码：1225 / 1227

页数：3

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