Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-β-Lactamase Clones (VIM-2,-5,-6, and-11 and the Newly Characterized VIM-18)

被引：53

作者：

Castanheira, Mariana ^{[1
]}

Bell, Jan M. ^{[2
]}

Turnidge, John D. ^{[2
]}

Mathai, Dillip ^{[3
]}

Jones, Ronald N. ^{[1
,4
]}

机构：

[1] JMI Labs, N Liberty, IA 52317 USA

[2] Womens & Childrens Hosp, Adelaide, SA, Australia

[3] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India

[4] Tufts Univ, Sch Med, Boston, MA 02110 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 03期

关键词：

D O I：

10.1128/AAC.01011-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among 57 metallo-beta-lactamase (M beta L)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized bla(VIM) gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of bla(VIM-2)-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of bla(VIM) types and M beta L-carrying integrons.

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页码：1225 / 1227

页数：3

相关论文

共 9 条

[1]

*CLSI, 2008, M100S18 CLSI S

[2] COMPARATIVE-STUDY OF 5 DIFFERENT DNA FINGERPRINT TECHNIQUES FOR MOLECULAR TYPING OF STREPTOCOCCUS-PNEUMONIAE STRAINS [J].

HERMANS, PWM ;

SLUIJTER, M ;

HOOGENBOEZEM, T ;

HEERSMA, H ;

VANBELKUM, A ;

DEGROOT, R .

JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (06) :1606-1612

[3] Global epidemiology of antimicrobial resistance among community-acquired and nosocomial pathogens: A five-year summary from the SENTRY Antimicrobial Surveillance Program (1997-2001) [J].

Jones, RN .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 24 (01) :121-133

[4] Rapid detection and identification of metallo-β-lactamase-encoding genes by multiplex real-time PCR assay and melt curve analysis [J].

Mendes, Rodrigo E. ;

Kiyota, Katia A. ;

Monteiro, Jussimara ;

Castanheira, Mariana ;

Andrade, Soraya S. ;

Gales, Ana C. ;

Pignatari, Antonio C. C. ;

Tufik, Sergio .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (02) :544-547

[5] Characterization of VIM-2, a carbapenem-hydrolyzing metallo-β-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France [J].

Poirel, L ;

Naas, T ;

Nicolas, D ;

Collet, L ;

Bellais, S ;

Cavallo, JD ;

Nordmann, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (04) :891-897

[6] INTERPRETING CHROMOSOMAL DNA RESTRICTION PATTERNS PRODUCED BY PULSED-FIELD GEL-ELECTROPHORESIS - CRITERIA FOR BACTERIAL STRAIN TYPING [J].

TENOVER, FC ;

ARBEIT, RD ;

GOERING, RV ;

MICKELSEN, PA ;

MURRAY, BE ;

PERSING, DH ;

SWAMINATHAN, B .

JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (09) :2233-2239

[7] blaVIM-2-Harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3′ conserved sequence [J].

Toleman, Mark A. ;

Vinodh, Hemalatha ;

Sekar, Uma ;

Kamat, Vijaylakshmi ;

Walsh, Timothy R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (07) :2636-2638

[8] Guidelines for the validation and application of typing methods for use in bacterial epidemiology [J].

van Belkum, A. ;

Tassios, P. T. ;

Dijkshoorn, L. ;

Haeggman, S. ;

Cookson, B. ;

Fry, N. K. ;

Fussing, V. ;

Green, J. ;

Feil, E. ;

Gerner-Smidt, P. ;

Brisse, S. ;

Struelens, M. .

CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 :1-46

[9] Metallo-β-lactamases:: the quiet before the storm? [J].

Walsh, TR ;

Toleman, MA ;

Poirel, L ;

Nordmann, P .

CLINICAL MICROBIOLOGY REVIEWS, 2005, 18 (02) :306-+