Cancer Microbiome; Opportunities and Challenges

被引:6
作者
Nallanchakravarthula, Srivathsa [1 ]
Amruta, Narayanappa [2 ]
Ramamurthy, Chitteti [1 ,3 ]
机构
[1] UkaTarsadia Univ, CG Bhakta Inst Biotechnol, Maliba Campus, Tarsadi, Gujarat, India
[2] Tulane Univ, Dept Neurosurg, New Orleans, LA 70118 USA
[3] Indian Inst Technol Delhi, Kusuma Sch Biol Sci, New Delhi, India
关键词
Cancer; microbiome; tumor microenvironment; metabolic plasticity; probiotics; therapeutics; CHAIN FATTY-ACIDS; GUT MICROBIOTA; FECAL MICROBIOTA; BACTERIAL TRANSLOCATION; LACTOBACILLUS-PLANTARUM; INTESTINAL MICROBIOTA; DIETARY PATTERNS; PROBIOTICS; METABOLITES; MICROFLORA;
D O I
10.2174/1871530320999200818134942
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Microbe-host association has emerged as a modulator in modern medicine. Cancer and its associated host microbes are collectively referred to as the cancer microbiome. The cancer microbiome is complex, and many aspects remain unclear including metabolic plasticity, microenvironment remodeling, cellular communications, and unique signatures within the host, all of which have a vital role in homeostasis and pathogenesis of host physiology. However, the role of the microbiome in cancer initiation, progression, and therapy is still poorly understood and remains to be explored. Objective: The objective of this review is to elucidate the role of the microbiome in cancer metabolism and the tumor microenvironment. It also focuses on the importance of therapeutic opportunities and challenges in the manipulation of the cancer microbiome. Methods: A literature search was conducted on the role of the microbiome in cancer initiation, progression, and therapy. Conclusion: The tumor microenvironment and cancer metabolism are significant in host-microbiome interactions. The microbiome can modulate standard cancer therapies like chemotherapy and immunotherapy. Microbiome transplantation has also been demonstrated as an effective therapy against cancer. Furthermore, the modulation of the microbiome also has potential clinical outcomes in modern medicine.
引用
收藏
页码:215 / 229
页数:15
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