Blue light mediated C-H arylation of heteroarenes using TiO2 as an immobilized photocatalyst in a continuous-flow microreactor

被引:55
作者
Fabry, David C. [1 ]
Ho, Yee Ann [1 ]
Zapf, Ralf [2 ]
Tremel, Wolfgang [3 ]
Panthoefer, Martin [3 ]
Rueping, Magnus [1 ]
Rehm, Thomas H. [2 ]
机构
[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany
[2] Fraunhofer ICT IMM, Carl Zeiss Str 18-20, D-55129 Mainz, Germany
[3] Johannes Gutenberg Univ Mainz, Inst Inorgan Chem & Analyt Chem, Duesbergweg 10-14, D-55128 Mainz, Germany
基金
欧洲研究理事会;
关键词
SELECTIVE AEROBIC OXIDATION; FALLING FILM MICROREACTOR; PHOTOREDOX CATALYSIS; DIOXIDE ABSORPTION; TITANIUM-DIOXIDE; REACTOR; PHOTOCHEMISTRY; HYDROGENATION; METHANOL; BATCH;
D O I
10.1039/c7gc00497d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Titanium dioxide was applied as an immobilized photocatalyst in a microstructured falling film reactor for the continuous-flow C-H arylation of heteroarenes with aryldiazonium salts as the starting material. Detailed investigations of the catalyst and a successful long-term run proved its excellent usability for this process. Very good yields up to 99% were achieved with broad substrate scope and were compared with batch synthesis. The transfer to the continuous-flow mode revealed an impressive boost in reactor performance solely resulting from the improved irradiation and contact of the catalyst, substrate and light.
引用
收藏
页码:1911 / 1918
页数:8
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