Advances in quantum dot-based biosensors for DNA-modifying enzymes assay

被引：41

作者：

Zhang, Qian ^{[1
]}

Zhang, Xinyi ^{[2
]}

Ma, Fei ^{[3
]}

Zhang, Chun-yang ^{[1
]}

机构：

[1] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Peoples R China

[2] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China

[3] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China

来源：

COORDINATION CHEMISTRY REVIEWS | 2022年 / 469卷

关键词：

Quantum dots; Biosensors; DNA glycosylase; DNA methyltransferase; Alkaline phosphatase; Telomerase; RESONANCE ENERGY-TRANSFER; T4 POLYNUCLEOTIDE KINASE; ALKALINE-PHOSPHATASE ACTIVITY; HIGHLY SENSITIVE DETECTION; TELOMERASE ACTIVITY; EXCISION-REPAIR; THYMINE DNA; MULTICOLOR COLOCALIZATION; ULTRASENSITIVE DETECTION; GLYCOSYLASE DOMAIN;

D O I：

10.1016/j.ccr.2022.214674

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

DNA-modifying enzymes participate in various genetic functions (e.g., DNA replication, repairing, and recombination) through alternating certain DNA sequence, and the malfunction of DNA-modifying enzymes may disturb the normal genetic functions and consequently causes diverse human diseases. DNA-modifying enzymes may serve as the valuable diagnosis biomarkers and therapeutic targets, and the detection of DNA-modifying enzymes is essential to fundamental research, anticancer-drug discovery, and clinical diagnosis. Quantum dots (QDs) have many excellent electronic and optical characteristics, facilitating their biosensing and bioimaging applications. We review the development of QDs-based biosensors for DNA-modifying enzyme assays, and discuss current challenges and future directions in this field.(c) 2022 Elsevier B.V. All rights reserved.

引用

页数：17

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