Immune reconstitution and survival of patients with parvovirus B19 related pure red cell aplasia after haplo-PBSCT

被引：4

作者：

Zhou, Xiao ^{[1
,2
]}

Jiang, Peiyao ^{[1
,2
]}

Gao, Lu ^{[1
,2
]}

Yang, Jun ^{[1
,2
]}

Cai, Yu ^{[1
,2
]}

Tong, Yin ^{[1
,2
]}

Qiu, Huiying ^{[1
,2
]}

Huang, Chongmei ^{[1
,2
]}

Zhou, Kun ^{[1
,2
]}

Xu, Xiaowei ^{[1
,2
]}

Niu, Jiahua ^{[1
,2
]}

Xia, Xinxin ^{[1
,2
]}

Zhang, Ying ^{[1
,2
]}

Shen, Chang ^{[1
,2
]}

Wei, Yu ^{[1
,2
]}

Shao, Jie ^{[1
,2
]}

Song, Xianmin ^{[1
,2
]}

Wan, Liping ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Hematol, Sch Med, 100 Haining Rd, Shanghai 200080, Peoples R China

[2] Shanghai Sci & Technol Comm STCSM, Engn Technol Res Ctr Cell Therapy & Clin Translat, 100 Haining Rd, Shanghai 200080, Peoples R China

来源：

ANNALS OF HEMATOLOGY | 2022年 / 101卷 / 06期

关键词：

Parvovirus B19; Pure red cell aplasia; Immune reconstitution; HLA-haploidentical; Peripheral blood stem cell transplantation; TRANSPLANT RECIPIENTS; INFECTION; DISEASE;

D O I：

10.1007/s00277-022-04831-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Parvovirus B19 (PvB19) infection and PvB19 related pure red cell aplasia (PRCA) in recipients with allogeneic hematopoietic stem cell transplantation have been reported sporadically. However, clinical studies with large sample sizes are lacking, especially in patients undergoing HLA-haploidentical peripheral blood stem cell transplantation (haplo-PBSCT). In addition, clinical features, immune reconstitution, and outcomes of these patients are not clear. We conducted a retrospective analysis of 164 patients who received haplo-PBSCT with low-dose anti-thymocyte globulin (ATG) plus low-dose posttransplant cyclophosphamide (PTCy)-based regimen as graft-versus-host disease (GVHD) prophylaxis. We analyzed the incidence of PvB19 related PRCA and compared the clinical characteristics, immune reconstitution, incidence of GVHD, relapse rate, and survival between patients with and without PvB19 related PRCA. A total of 14 (8.5%) recipients developed PvB19 related PRCA after a median of 5.3 months after haplo-PBSCT. These patients with PvB19 related PRCA had slower immune reconstitution, but similar incidences of GVHD, relapse rate, and overall survival compared with recipients without PvB19 related PRCA. PvB19 related PRCA indicated relative delayed and poor immune reconstitution of the recipients early after haplo-PBSCT. PvB19 related PRCA had no effects on GVHD, relapse, and survival.

引用

页码：1333 / 1342

页数：10

共 31 条

[1] Autologous peripheral blood progenitor cells are a potential source of parvovirus B19 infection [J].