Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius

被引：11

作者：

Li, Fei

Ma, Jie

Li, Chuang-Jun

Yang, Jing-Zhi

Zhang, Dan

Chen, Xiao-Guang

Zhang, Dong-Ming ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY | 2017年 / 135卷

基金：

中国国家自然科学基金;

关键词：

Euonymus oblongifolius; Celastraceae; Isopimarane diterpenoid; Nitric oxide production; Cytotoxicity; SESQUITERPENE POLYOL ESTERS; ROOTS;

D O I：

10.1016/j.phytochem.2016.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven isopimarane diterpenes and one abietane diterpene, together with six known sesquiterpene derivatives, were isolated from the stems of Euonymus oblongifolius. Their structures were elucidated on the basis of spectroscopic analyses, and the absolute configuration of euonymusisopimaric acid A was confirmed by single-crystal X-ray crystallographic analysis using anomalous scattering of Cu K alpha radiation. All of the isolated compounds were evaluated for their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, and for their cytotoxic activity against five human cancer cell lines. Euonymusisopimaric acids A, E and F inhibited LPS-induced nitric oxide production in the murine microglia BV2 cell line, with IC50 values of 2.4, 4.8, and 1.6 mu M, respectively. Euonymusisopimaric acid B exhibited moderate cytotoxicity against A549 cell line growth, with an IC50 value of 2.6 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：144 / 150

页数：7

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