Evaluation of biological synthesized platinum nanoparticles using Ononidis radix extract on the cell lung carcinoma A549

被引：29

作者：

Dobrucka, Renata ^{[1
]}

Romaniuk-Drapala, Aleksandra ^{[2
]}

Kaczmarek, Mariusz ^{[3
]}

机构：

[1] Poznan Univ Econ, Fac Commod Sci, Dept Ind Prod Qual & Ecol, Al Niepodleglosci 10, PL-61875 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Clin Chem & Mol Diagnost, 49 Przybyszewskiego St, PL-60355 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Immunol Chair Clin Immunol, Rokietnicka 5D, PL-60806 Poznan, Poland

来源：

BIOMEDICAL MICRODEVICES | 2019年 / 21卷 / 03期

关键词：

Platinum nanopartilces; Green synthesis; Anticancer activity; GREEN SYNTHESIS; METAL NANOPARTICLES; CANCER-CELLS; SPINOSA L; BIOSYNTHESIS; GOLD; LEAF;

D O I：

10.1007/s10544-019-0424-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Due to the search for new methods for synthesizing nanomaterials, this work proposes the biological synthesis of platinum nanoparticles using Ononidis radix extract. The synthesized platinum nanoparticles were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The examination conducted by means of Transmission Electron Microscopy showed the presence of spherical and hexagonal platinum nanoparticles. Atomic Force Microscopy indicated the presence of locally agglomerated nanoparticles whose size was about 4nm. The study also examined the influence of platinum nanoparticles on human non-small cell lung carcinoma cells A549. It was found that the mortality of cells cultured together with platinum nanoparticles increased, and the proliferative activity of A549 cells decreased gradually over time in proportion to the increasing concentration of the test substance.

引用

页数：10

共 35 条

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