A colorimetric and near-infrared fluorescent probe with high sensitivity and selectivity for acid phosphatase and inhibitor screening

被引：77

作者：

Xu, Yongqian ^{[1
]}

Li, Benhao ^{[2
]}

Xiao, Liangliang ^{[1
]}

Ouyang, Jia ^{[5
]}

Sun, Shiguo ^{[1
]}

Pang, Yi ^{[3
,4
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Yangling 712100, Peoples R China

[2] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710062, Peoples R China

[3] Univ Akron, Dept Chem, Akron, OH 44325 USA

[4] Univ Akron, Maurice Morton Inst Polymer Sci, Akron, OH 44325 USA

[5] Northwestern Polytech Univ, Sch Mat Sci & Engn, Xian 710062, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 63期

基金：

中国国家自然科学基金;

关键词：

TURN-ON DETECTION; ALKALINE-PHOSPHATASE; PERYLENE PROBE; PROSTATE-CANCER; CONJUGATED POLYELECTROLYTE; ASSAY; BIOMARKERS; PROTEIN; AGGREGATION; GLUTATHIONE;

D O I：

10.1039/c3cc49254k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dual-channel including a colorimetric and fluorescent probe based on the aggregation-caused quenching (ACQ) and enzymolysis approach has been presented to screen acid phosphatase (ACP) and its inhibitor. Moreover, the ACP activity was determined by real time assay.

引用

页码：8677 / 8680

页数：4

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