A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive chemotherapy

被引：27

作者：

Kesavan, Mookkandi Palsamy ^{[1
]}

Kotla, Niranjan G. ^{[2
]}

Ayyanaar, Srinivasan ^{[1
]}

Kumar, Gujuluva Gangatharan Vinoth ^{[1
]}

Rajagopal, Gurusamy ^{[3
]}

Sivaraman, Gandhi ^{[4
]}

Webster, Thomas J. ^{[5
]}

Rajesh, Jegathalaprathaban ^{[1
]}

机构：

[1] Mohamed Sathak Engn Coll, Chem Res Ctr, Kilakarai, Tamilnadu, India

[2] Natl Univ Ireland Galway, Ctr Res Med Devices CURAM, Galway, Ireland

[3] Chikkanna Govt Arts Coll, PG & Res Dept Chem, Tiruppur, Tamilnadu, India

[4] Madurai Kamaraj Univ, Sch Chem, Madurai, Tamil Nadu, India

[5] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 05期

关键词：

Iron oxide nanoparticles; Anti-cancer drug delivery; Biosurfactant; Serum protein binding; Theranostic nanocages; Camptothecin and luotonin A; SERUM-ALBUMIN; NANOPARTICLES; ANTICANCER; DELIVERY; RESISTANCE; LUOTONIN; CO;

D O I：

10.1016/j.nano.2018.04.013

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this work, a theranostic nanocage system was developed for the targeted delivery of the anti-cancer agents camptothecin (CPT) and luotonin A (LuA). The core of the nanocage system (Fe3O4@OA-AD-SP NCs) was formed by biogenically synthesized Fe3O4 nanoparticles (NPs) decorated with a model anti-cancer drug (AD) and biosurfactant saponin (SP). The Fe3O4@OA-AD-SP NCs showed a high lipophilic AD loading efficiency (>80%) and a controlled pH-responsive drug release in stimulated cancerous cells in pH 6.4 media buffer. In addition, Fe3O4@OA-AD-SP NCs exhibited better serum protein binding efficacy at physiological pH values (7.4), furthering the important role of SP surface decoration. Particularly, these NCs showed better chemotherapeutic efficacy when examined in MCF-7 and HeLa cancer cell lines with a specific targeting capacity. Therefore, this study provides a new nano platform based on magnetic targeting and pH responsive lipophilic anticancer drug delivery to the cancer site. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1643 / 1654

页数：12

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