A simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature

被引：14

作者：

Desai, Uday V. ^{[1
]}

Kulkarni, Makarand A. ^{[1
]}

Pandit, Kapil S. ^{[1
]}

Kulkarni, Aparna M. ^{[1
]}

Wadgaonkar, Prakash P. ^{[2
]}

机构：

[1] Shivaji Univ, Dept Chem, Div Organ Chem, Kolhapur 416004, Maharashtra, India

[2] Natl Chem Lab, Polymer Sci & Engn Div, CSIR, Pune, Maharashtra, India

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2014年 / 7卷 / 03期

关键词：

multicomponent reactions; diethylamine; pyridine-3,5-dicarbonitriles; organocatalyst; green chemistry; HIGHLY SUBSTITUTED PYRIDINES; ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; MULTICOMPONENT SYNTHESIS; FUNCTIONALIZED PYRIDINES; 3-COMPONENT SYNTHESIS; POTASSIUM PHOSPHATE; ROOM-TEMPERATURE; IONIC LIQUID; ONE-STEP;

D O I：

10.1080/17518253.2014.925144

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for "green synthesis."

引用

页码：228 / 235

页数：8

共 24 条

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