A simple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature

被引：14
|
作者：
Desai, Uday V. [1 ]
Kulkarni, Makarand A. [1 ]
Pandit, Kapil S. [1 ]
Kulkarni, Aparna M. [1 ]
Wadgaonkar, Prakash P. [2 ]
机构：
[1] Shivaji Univ, Dept Chem, Div Organ Chem, Kolhapur 416004, Maharashtra, India
[2] Natl Chem Lab, Polymer Sci & Engn Div, CSIR, Pune, Maharashtra, India
来源：
GREEN CHEMISTRY LETTERS AND REVIEWS | 2014年 / 7卷 / 03期
关键词：
multicomponent reactions; diethylamine; pyridine-3,5-dicarbonitriles; organocatalyst; green chemistry; HIGHLY SUBSTITUTED PYRIDINES; ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; MULTICOMPONENT SYNTHESIS; FUNCTIONALIZED PYRIDINES; 3-COMPONENT SYNTHESIS; POTASSIUM PHOSPHATE; ROOM-TEMPERATURE; IONIC LIQUID; ONE-STEP;
D O I：
10.1080/17518253.2014.925144
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for "green synthesis."
引用
收藏
页码：228 / 235
页数：8
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