Enabling membrane protein structure and dynamics with X-ray free electron lasers

被引：19

作者：

Feld, Geoffrey K. ^{[1
]}

Frank, Matthias ^{[2
]}

机构：

[1] Lawrence Livermore Natl Lab, Biosci & Biotechnol Div, Phys & Life Sci Directorate, Livermore, CA 94550 USA

[2] Lawrence Livermore Natl Lab, Div Phys, Phys & Life Sci Directorate, Livermore, CA 94550 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 27卷

关键词：

CRYSTALLOGRAPHIC DATA; PHOTOSYSTEM-II; DIFFRACTION; CRYSTALLIZATION; OPPORTUNITIES; MICROCRYSTALS; NANOCRYSTALS; RESOLUTION; CAUGHT;

D O I：

10.1016/j.sbi.2014.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Determining the three-dimensional structures and dynamics of membrane proteins remains one of the great challenges of modern biology. The recent availability of X-ray free electron laser (XFEL) light sources has opened the door to a new and revolutionary approach to performing X-ray analysis of these important biomolecules. Recent advances in sample delivery, data reduction, and phasing have enabled the high-resolution structural probing of membrane proteins at room temperature. While considerable challenges remain, the recent developments described in this review may ultimately provide structural biologists with powerful tools for obtaining unprecedented atomic-scale and dynamic visualization of membrane proteins at near-physiological conditions.

引用

页码：69 / 78

页数：10

共 55 条

[1]

Alonso-Mori R, 2012, P NATL ACAD SCI USA, V109

[2] A multi-crystal wavelength dispersive x-ray spectrometer [J].

Alonso-Mori, Roberto ;

Kern, Jan ;

Sokaras, Dimosthenis ;

Weng, Tsu-Chien ;

Nordlund, Dennis ;

Tran, Rosalie ;

Montanez, Paul ;

Delor, James ;

Yachandra, Vittal K. ;

Yano, Junko ;

Bergmann, Uwe .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2012, 83 (07)

[3] Time-resolved protein nanocrystallography using an X-ray free-electron laser [J].

Aquila, Andrew ;

Hunter, Mark S. ;

Doak, R. Bruce ;

Kirian, Richard A. ;

Fromme, Petra ;

White, Thomas A. ;

Andreasson, Jakob ;

Arnlund, David ;

Bajt, Sasa ;

Barends, Thomas R. M. ;

Barthelmess, Miriam ;

Bogan, Michael J. ;

Bostedt, Christoph ;

Bottin, Herve ;

Bozek, John D. ;

Caleman, Carl ;

Coppola, Nicola ;

Davidsson, Jan ;

DePonte, Daniel P. ;

Elser, Veit ;

Epp, Sascha W. ;

Erk, Benjamin ;

Fleckenstein, Holger ;

Foucar, Lutz ;

Frank, Matthias ;

Fromme, Raimund ;

Graafsma, Heinz ;

Grotjohann, Ingo ;

Gumprecht, Lars ;

Hajdu, Janos ;

Hampton, Christina Y. ;

Hartmann, Andreas ;

Hartmann, Robert ;

Hauriege, Stefan ;

Hauser, Guenter ;

Hirsemann, Helmut ;

Holl, Peter ;

Holton, James M. ;

Hoemke, Andre ;

Johansson, Linda ;

Kimmel, Nils ;

Kassemeyer, Stephan ;

Krasniqi, Faton ;

Kuehnel, Kaiuwe ;

Liang, Mengning ;

Lomb, Lukas ;

Malmerberg, Erik ;

Marchesini, Stefano ;

Martin, Andrew V. ;

Maia, Filipe R. N. C. .

OPTICS EXPRESS, 2012, 20 (03) :2706-2716

[4] De novo protein crystal structure determination from X-ray free-electron laser data [J].

Barends, Thomas R. M. ;

Foucar, Lutz ;

Botha, Sabine ;

Doak, R. Bruce ;

Shoeman, Robert L. ;

Nass, Karol ;

Koglin, Jason E. ;

Williams, Garth J. ;

Boutet, Sebastien ;

Messerschmidt, Marc ;

Schlichting, Ilme .

NATURE, 2014, 505 (7482) :244-+

[5] Anomalous signal from S atoms in protein crystallographic data from an X-ray free-electron laser [J].

Barends, Thomas R. M. ;

Foucar, Lutz ;

Shoeman, Robert L. ;

Bari, Sadia ;

Epp, Sascha W. ;

Hartmann, Robert ;

Hauser, Gunter ;

Huth, Martin ;

Kieser, Christian ;

Lomb, Lukas ;

Motomura, Koji ;

Nagaya, Kiyonobu ;

Schmidt, Carlo ;

Strecker, Rafael ;

Anielski, Denis ;

Boll, Rebecca ;

Erk, Benjamin ;

Fukuzawa, Hironobu ;

Hartmann, Elisabeth ;

Hatsui, Takaki ;

Holl, Peter ;

Inubushi, Yuichi ;

Ishikawa, Tetsuya ;

Kassemeyer, Stephan ;

Kaiser, Christian ;

Koeck, Frank ;

Kunishima, Naoki ;

Kurka, Moritz ;

Rolles, Daniel ;

Rudek, Benedikt ;

Rudenko, Artem ;

Sato, Takahiro ;

Schroeter, Claus-Dieter ;

Soltau, Heike ;

Strueder, Lothar ;

Tanaka, Tomoyuki ;

Togashi, Tadashi ;

Tono, Kensuke ;

Ullrich, Joachim ;

Yase, Satoshi ;

Wada, Shin-ichi ;

Yao, Makoto ;

Yabashi, Makina ;

Ueda, Kiyoshi ;

Schlichting, Ilme .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2013, 69 :838-842

[6]

Barty A, 2012, NAT PHOTONICS, V6, P35, DOI [10.1038/NPHOTON.2011.297, 10.1038/nphoton.2011.297]

[7] X-ray Free Electron Lasers Motivate Bioanalytical Characterization of Protein Nanocrystals: Serial Femtosecond Crystallography [J].

Bogan, Michael J. .

ANALYTICAL CHEMISTRY, 2013, 85 (07) :3464-3471

[8] High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography [J].

Boutet, Sebastien ;

Lomb, Lukas ;

Williams, Garth J. ;

Barends, Thomas R. M. ;

Aquila, Andrew ;

Doak, R. Bruce ;

Weierstall, Uwe ;

DePonte, Daniel P. ;

Steinbrener, Jan ;

Shoeman, Robert L. ;

Messerschmidt, Marc ;

Barty, Anton ;

White, Thomas A. ;

Kassemeyer, Stephan ;

Kirian, Richard A. ;

Seibert, M. Marvin ;

Montanez, Paul A. ;

Kenney, Chris ;

Herbst, Ryan ;

Hart, Philip ;

Pines, Jack ;

Haller, Gunther ;

Gruner, Sol M. ;

Philipp, Hugh T. ;

Tate, Mark W. ;

Hromalik, Marianne ;

Koerner, Lucas J. ;

van Bakel, Niels ;

Morse, John ;

Ghonsalves, Wilfred ;

Arnlund, David ;

Bogan, Michael J. ;

Caleman, Carl ;

Fromme, Raimund ;

Hampton, Christina Y. ;

Hunter, Mark S. ;

Johansson, Linda C. ;

Katona, Gergely ;

Kupitz, Christopher ;

Liang, Mengning ;

Martin, Andrew V. ;

Nass, Karol ;

Redecke, Lars ;

Stellato, Francesco ;

Timneanu, Nicusor ;

Wang, Dingjie ;

Zatsepin, Nadia A. ;

Schafer, Donald ;

Defever, James ;

Neutze, Richard .

SCIENCE, 2012, 337 (6092) :362-364

[9] The Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) [J].

Boutet, Sebastien ;

Williams, Garth J. .

NEW JOURNAL OF PHYSICS, 2010, 12

[10] Femtosecond X-ray protein nanocrystallography [J].

Chapman, Henry N. ;

Fromme, Petra ;

Barty, Anton ;

White, Thomas A. ;

Kirian, Richard A. ;

Aquila, Andrew ;

Hunter, Mark S. ;

Schulz, Joachim ;

DePonte, Daniel P. ;

Weierstall, Uwe ;

Doak, R. Bruce ;

Maia, Filipe R. N. C. ;

Martin, Andrew V. ;

Schlichting, Ilme ;

Lomb, Lukas ;

Coppola, Nicola ;

Shoeman, Robert L. ;

Epp, Sascha W. ;

Hartmann, Robert ;

Rolles, Daniel ;

Rudenko, Artem ;

Foucar, Lutz ;

Kimmel, Nils ;

Weidenspointner, Georg ;

Holl, Peter ;

Liang, Mengning ;

Barthelmess, Miriam ;

Caleman, Carl ;

Boutet, Sebastien ;

Bogan, Michael J. ;

Krzywinski, Jacek ;

Bostedt, Christoph ;

Bajt, Sasa ;

Gumprecht, Lars ;

Rudek, Benedikt ;

Erk, Benjamin ;

Schmidt, Carlo ;

Hoemke, Andre ;

Reich, Christian ;

Pietschner, Daniel ;

Strueder, Lothar ;

Hauser, Guenter ;

Gorke, Hubert ;

Ullrich, Joachim ;

Herrmann, Sven ;

Schaller, Gerhard ;

Schopper, Florian ;

Soltau, Heike ;

Kuehnel, Kai-Uwe ;

Messerschmidt, Marc .

NATURE, 2011, 470 (7332) :73-U81

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