Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development

被引：63

作者：

Melero, Jose A. ^{[1
,2
]}

Mas, Vicente ^{[1
,2
]}

McLellan, Jason S. ^{[3
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Biol Viral, Madrid, Spain

[2] Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid, Spain

[3] Geisel Sch Med Dartmouth, Dept Biochem & Cell Biol, Hanover, NH USA

来源：

VACCINE | 2017年 / 35卷 / 03期

基金：

美国国家卫生研究院;

关键词：

RSV glycoproteins and vaccine development; NEUTRALIZING MONOCLONAL-ANTIBODIES; ATTACHMENT PROTEIN-G; 2 DISTINCT SITES; FUSION PROTEIN; F-PROTEIN; O-GLYCOSYLATION; SOLUBLE FORM; SUBGROUP-B; RSV F; IDENTIFICATION;

D O I：

10.1016/j.vaccine.2016.09.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Extraordinary progress in the structure and immunobiology of the human respiratory syncytial virus glycoproteins has been accomplished during the last few years. Determination of the fusion (F) glycoprotein structure folded in either the prefusion or the postfusion conformation was an inspiring breakthrough not only to understand the structural changes associated with the membrane fusion process but additionally to appreciate the antigenic intricacies of the F protein. Furthermore, these developments have opened new avenues for structure-based designs of promising hRSV vaccine candidates. Finally, recent advances in our knowledge of the attachment (G) glycoprotein and its interaction with cell-surface receptors have revitalized interest in this molecule as a vaccine, as well as its role in hRSV immunobiology. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：461 / 468

页数：8

共 94 条

[1] Taxonomy of the order Mononegavirales: update 2016 [J].

Afonso, Claudio L. ;

Amarasinghe, Gaya K. ;

Banyai, Krisztian ;

Bao, Yiming ;

Basler, Christopher F. ;

Bavari, Sina ;

Bejerman, Nicolas ;

Blasdell, Kim R. ;

Briand, Francois-Xavier ;

Briese, Thomas ;

Bukreyev, Alexander ;

Calisher, Charles H. ;

Chandran, Kartik ;

Cheng, Jiasen ;

Clawson, Anna N. ;

Collins, Peter L. ;

Dietzgen, Ralf G. ;

Dolnik, Olga ;

Domier, Leslie L. ;

Duerrwald, Ralf ;

Dye, John M. ;

Easton, Andrew J. ;

Ebihara, Hideki ;

Farkas, Szilvia L. ;

Freitas-Astua, Juliana ;

Formenty, Pierre ;

Fouchier, Ron A. M. ;

Fu, Yanping ;

Ghedin, Elodie ;

Goodin, Michael M. ;

Hewson, Roger ;

Horie, Masayuki ;

Hyndman, Timothy H. ;

Jiang, Daohong ;

Kitajima, Elliot W. ;

Kobinger, Gary P. ;

Kondo, Hideki ;

Kurath, Gael ;

Lamb, Robert A. ;

Lenardon, Sergio ;

Leroy, Eric M. ;

Li, Ci-Xiu ;

Lin, Xian-Dan ;

Liu, Lijiang ;

Longdon, Ben ;

Marton, Szilvia ;

Maisner, Andrea ;

Muhlberger, Elke ;

Netesov, Sergey V. ;

Nowotny, Norbert .

ARCHIVES OF VIROLOGY, 2016, 161 (08) :2351-2360

[2] NEUTRALIZATION OF RESPIRATORY SYNCYTIAL VIRUS BY INDIVIDUAL AND MIXTURES OF F-PROTEIN AND G-PROTEIN MONOCLONAL-ANTIBODIES [J].

ANDERSON, LJ ;

BINGHAM, P ;

HIERHOLZER, JC .

JOURNAL OF VIROLOGY, 1988, 62 (11) :4232-4238

[3] ANTIGENIC CHARACTERIZATION OF RESPIRATORY SYNCYTIAL VIRUS-STRAINS WITH MONOCLONAL-ANTIBODIES [J].

ANDERSON, LJ ;

HIERHOLZER, JC ;

TSOU, C ;

HENDRY, RM ;

FERNIE, BF ;

STONE, Y ;

MCINTOSH, K .

JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (04) :626-633

[4] CHARACTERIZATION OF 2 ANTIGENIC SITES RECOGNIZED BY NEUTRALIZING MONOCLONAL-ANTIBODIES DIRECTED AGAINST THE FUSION GLYCOPROTEIN OF HUMAN RESPIRATORY SYNCYTIAL VIRUS [J].

ARBIZA, J ;

TAYLOR, G ;

LOPEZ, JA ;

FURZE, J ;

WYLD, S ;

WHYTE, P ;

STOTT, EJ ;

WERTZ, G ;

SULLENDER, W ;

TRUDEL, M ;

MELERO, JA .

JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2225-2234

[5] NEUTRALIZATION EPITOPES OF THE F-GLYCOPROTEIN OF RESPIRATORY SYNCYTIAL VIRUS - EFFECT OF MUTATION UPON FUSION FUNCTION [J].

BEELER, JA ;

COELINGH, KV .

JOURNAL OF VIROLOGY, 1989, 63 (07) :2941-2950

[6] A Respiratory Syncytial Virus (RSV) Anti-G Protein F(ab′)2 Monoclonal Antibody Suppresses Mucous Production and Breathing Effort in RSV rA2-line19F-Infected BALB/c Mice [J].

Boyoglu-Barnum, Seyhan ;

Gaston, Kelsey A. ;

Todd, Sean O. ;

Boyoglu, Cemil ;

Chirkova, Tatiana ;

Barnum, Thomas R. ;

Jorquera, Patricia ;

Haynes, Lia M. ;

Tripp, Ralph A. ;

Moore, Martin L. ;

Anderson, Larry J. .

JOURNAL OF VIROLOGY, 2013, 87 (20) :10955-10967

[7] The Secreted Form of Respiratory Syncytial Virus G Glycoprotein Helps the Virus Evade Antibody-Mediated Restriction of Replication by Acting as an Antigen Decoy and through Effects on Fc Receptor-Bearing Leukocytes [J].

Bukreyev, Alexander ;

Yang, Lijuan ;

Fricke, Jens ;

Cheng, Lily ;

Ward, Jerrold M. ;

Murphy, Brian R. ;

Collins, Peter L. .

JOURNAL OF VIROLOGY, 2008, 82 (24) :12191-12204

[8] Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies [J].

Calder, LJ ;

González-Reyes, L ;

García-Barreno, B ;

Wharton, SA ;

Skehel, LJ ;

Wiley, DC ;

Melero, JA .

VIROLOGY, 2000, 271 (01) :122-131

[9] Molecular epidemiology of respiratory syncytial virus [J].

Cane, PA .

REVIEWS IN MEDICAL VIROLOGY, 2001, 11 (02) :103-116

[10] CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells [J].

Chirkova, Tatiana ;

Lin, Songbai ;

Oomens, Antonius G. P. ;

Gaston, Kelsey A. ;

Boyoglu-Barnum, Seyhan ;

Meng, Jia ;

Stobart, Christopher C. ;

Cotton, Calvin U. ;

Hartert, Tina V. ;

Moore, Martin L. ;

Ziady, Assem G. ;

Anderson, Larry J. .

JOURNAL OF GENERAL VIROLOGY, 2015, 96 :2543-2556

← 1 2 3 4 5 6 7 8 9 10 →