Plasma amino acid profiles of breast cancer patients early in the trajectory of the disease differ from healthy comparison groups

被引：23

作者：

Barnes, Tyler ^{[1
]}

Bell, Kirsten ^{[2
]}

DiSebastiano, Katie M. ^{[1
]}

Vance, Vivienne ^{[3
]}

Hanning, Rhona ^{[4
]}

Russell, Caryl ^{[1
]}

Dubin, Joel A. ^{[4
,5
]}

Bahl, Mala ^{[6
]}

Califaretti, Nadia ^{[6
]}

Campbell, Carolyn ^{[6
]}

Mourtzakis, Marina ^{[1
]}

机构：

[1] Univ Waterloo, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada

[2] McMaster Univ, Dept Kinesiol, Hamilton, ON L8S 4L8, Canada

[3] Wilfred Laurier Univ, Dept Hlth Sci, Waterloo, ON N2L 3C5, Canada

[4] Univ Waterloo, Sch Publ Hlth & Hlth Syst, Waterloo, ON N2L 3G1, Canada

[5] Univ Waterloo, Dept Stat & Actuarial Sci, Waterloo, ON N2L 3G1, Canada

[6] Grand River Hosp, Grand River Reg Canc Ctr, Kitchener, ON N2G 1G3, Canada

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2014年 / 39卷 / 06期

基金：

加拿大健康研究院;

关键词：

leucine; glutamate; glutamine; histidine; threonine; essential amino acids; PROTEIN-SYNTHESIS; METABOLISM; SARCOPENIA; WOMEN; LUNG;

D O I：

10.1139/apnm-2013-0526

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

This study describes and compares fasting plasma amino acid profiles of breast cancer patients near the initiation of chemotherapy with those of healthy age-and body mass index-matched females (HM), as well as young healthy females (HY). Breast cancer patients had significantly greater glutamate and histidine concentrations and significantly lower threonine concentrations compared with HM and HY females independent of protein or caloric intake. These differences may be related to metabolic perturbations associated with the disease.

引用

页码：740 / 744

页数：5

共 22 条

[1] Body fat and poor diet in breast cancer women [J].

Amaral, P. ;

Miguel, R. ;

Mehdad, A. ;

Cruz, C. ;

Grillo, I. Monteiro ;

Camilo, M. ;

Ravasco, P. .

NUTRICION HOSPITALARIA, 2010, 25 (03) :456-461

[2] A comprehensive metabolic evaluation reveals impaired glucose metabolism and dyslipidemia in breast cancer patients early in the disease trajectory [J].

Bell, Kirsten E. ;

Di Sebastiano, Katie M. ;

Vance, Vivienne ;

Hanning, Rhona ;

Mitchell, Andrew ;

Quadrilatero, Joe ;

Russell, Caryl ;

Dubin, Joel A. ;

Bahl, Mala ;

Califaretti, Nadia ;

Campbell, Carolyn ;

Mourtzakis, Marina .

CLINICAL NUTRITION, 2014, 33 (03) :550-557

[3]

CASCINO A, 1995, ANTICANCER RES, V15, P507

[4]

Defa Li, 1999, Animal Feed Science and Technology, V78, P179, DOI 10.1016/S0377-8401(99)00005-X

[5] Glutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males [J].

Di Sebastiano, Katie M. ;

Bell, Kirsten E. ;

Barnes, Tyler ;

Weeraratne, Anushka ;

Premji, Tahira ;

Mourtzakis, Marina .

BRITISH JOURNAL OF NUTRITION, 2013, 110 (12) :2165-2172

[6] Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis [J].

Drummond, Micah J. ;

Rasmussen, Blake B. .

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2008, 11 (03) :222-226

[7] Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema [J].

Engelen, MPKJ ;

Schols, AMWJ ;

Does, JD ;

Deutz, NEP ;

Wouters, EFM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (01) :98-103

[8] Carnosine and cancer: a perspective [J].

Gaunitz, Frank ;

Hipkiss, Alan R. .

AMINO ACIDS, 2012, 43 (01) :135-142

[9] Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport [J].

Hack, V ;

Stutz, O ;

Kinscherf, R ;

Schykowski, M ;

Kellerer, M ;

Holm, E ;

Droge, W .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1996, 74 (06) :337-343

[10]

HEINRIKSON RL, 1984, ANAL BIOCHEM, V136, P65, DOI 10.1016/0003-2697(84)90307-5

← 1 2 3 →