Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets

被引：32

作者：

Zhou, Yangying ^{[1
]}

Lih, T. Mamie ^{[1
]}

Pan, Jianbo ^{[1
]}

Hoeti, Naseruddin ^{[1
]}

Dong, Mingming ^{[1
]}

Cao, Liwei ^{[1
]}

Hu, Yingwei ^{[1
]}

Cho, Kyung-Cho ^{[1
]}

Chen, Shao-Yung ^{[1
,2
]}

Eguez, Rodrigo Vargas ^{[1
]}

Gabrielson, Edward ^{[1
,3
]}

Chan, Daniel W. ^{[1
]}

Zhang, Hui ^{[1
,2
,3
,4
]}

Li, Qing Kay ^{[1
,3
]}

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[3] Johns Hopkins Med Inst, Dept Oncol, Sidney Kimmel Canc Ctr, Baltimore, MD 21224 USA

[4] Johns Hopkins Univ, Dept Urol, Baltimore, MD 21287 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2020年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Proteomic analysis; Data-independent acquisition; Tissue-enriched proteins; Cancer-associated proteins; Cancer therapeutic targets; HOUSEKEEPING GENES; POOR-PROGNOSIS; EXPRESSION; SENSITIVITY; RESISTANCE; MUTATIONS; SELECTION; RESOURCE; ANTIGENS; MAGE-A4;

D O I：

10.1186/s13045-020-01013-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Proteomic characterization of cancers is essential for a comprehensive understanding of key molecular aberrations. However, proteomic profiling of a large cohort of cancer tissues is often limited by the conventional approaches. Methods We present a proteomic landscape of 16 major types of human cancer, based on the analysis of 126 treatment-naive primary tumor tissues, 94 tumor-matched normal adjacent tissues, and 12 normal tissues, using mass spectrometry-based data-independent acquisition approach. Results In our study, a total of 8527 proteins were mapped to brain, head and neck, breast, lung (both small cell and non-small cell lung cancers), esophagus, stomach, pancreas, liver, colon, kidney, bladder, prostate, uterus and ovary cancers, including 2458 tissue-enriched proteins. Our DIA-based proteomic approach has characterized major human cancers and identified universally expressed proteins as well as tissue-type-specific and cancer-type-specific proteins. In addition, 1139 therapeutic targetable proteins and 21 cancer/testis (CT) antigens were observed. Conclusions Our discoveries not only advance our understanding of human cancers, but also have implications for the design of future large-scale cancer proteomic studies to assist the development of diagnostic and/or therapeutic targets in multiple cancers.

引用

页数：15

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