Gold Nanorod-Assembled PEGylated Graphene-Oxide Nanocomposites for Photothermal Cancer Therapy

被引：63

作者：

Dembereldorj, Uuriintuya ^{[1
]}

Choi, Seon Young ^{[2
,3
]}

Ganbold, Erdene-Ochir ^{[1
]}

Song, Nam Woong ^{[4
]}

Kim, Doseok ^{[5
]}

Choo, Jaebum ^{[6
]}

Lee, So Yeong ^{[2
,3
]}

Kim, Sehun ^{[7
,8
]}

Joo, Sang-Woo ^{[1
]}

机构：

[1] Soongsil Univ, Dept Chem, Seoul, South Korea

[2] Seoul Natl Univ, Coll Vet Med, Pharmacol Lab, Seoul, South Korea

[3] Seoul Natl Univ, Res Inst Vet Sci, Seoul, South Korea

[4] Korea Res Inst Stand & Sci, Taejon, South Korea

[5] Sogang Univ, Dept Phys, Seoul 100611, South Korea

[6] Hanyang Univ, Dept Bionano Engn, Ansan, South Korea

[7] Korea Adv Inst Sci & Technol, Mol Level Interface Res Ctr, Taejon 305701, South Korea

[8] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 2014年 / 90卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

NEAR-INFRARED ABSORBENCY; DELIVERY;

D O I：

10.1111/php.12212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gold nanorod-attached PEGylated graphene-oxide (AuNR-PEG-GO) nanocomposites were tested for a photothermal platform both in vitro and in vivo. Cytotoxicity of AuNR was reduced after encapsulation with PEG-GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB-eliminated AuNR-PEG-GO nanocomposites was examined using dark-field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR-PEG-GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe-lamp light (60Wcm(-2)) for 5min after treatment with the AuNR-PEG-GO nanocomposites for 24h. Cell viability significantly decreased by ~40% when the AuNR-PEG-GO-encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR-PEG-GO nanocomposites without any illumination. In vivo tumor experiments also indicated that HCl-treated AuNR-PEG-GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.

引用

页码：659 / 666

页数：8

共 28 条

[1] Graphene Oxide-Based Supramolecular Hydrogels for Making Nanohybrid Systems with Au Nanoparticles [J].