BRCA1/2 mutation carriers are potentially at higher cardiovascular risk

被引：27

作者：

Arts-de Jong, M. ^{[1
]}

Maas, A. H. E. M. ^{[2
]}

Massuger, L. F. ^{[1
]}

Hoogerbrugge, N. ^{[3
]}

de Hullu, J. A. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynecol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2014年 / 91卷 / 02期

关键词：

BRCA mutation; Cardiovascular disease; Risk-reducing salpingo-oophorectomy; Menopause; Cardio-oncology; INTIMA-MEDIA THICKNESS; HORMONE REPLACEMENT THERAPY; CORONARY-HEART-DISEASE; REDUCING SALPINGO-OOPHORECTOMY; EARLY BREAST-CANCER; PRIMARY OVARIAN INSUFFICIENCY; EARLY ESTROGEN PREVENTION; VASOMOTOR SYMPTOMS; WOMENS HEALTH; SUBCLINICAL ATHEROSCLEROSIS;

D O I：

10.1016/j.critrevonc.2014.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRCAI/2 mutation carriers have an elevated risk of developing breast and ovarian cancer at a relatively young age. Risk-reducing salpingooophorectomy is an established strategy to tremendously reduce the risk of ovarian cancer. It is recommended to perform this surgery at age 35-40 years (BRCA1) and at age 40-45 years (BRCA2) resulting in an early and abrupt menopause. BRCA1/2 mutation carriers are potentially at higher risk of cardiovascular diseases due to early surgical menopause, and cardiotoxic effects of adjuvant treatment for breast cancer. Furthermore, preliminary results of experimental studies suggest a possible causative function of the BRCA genes in cardiovascular risk. More research on cardiovascular health risks in BRCA1/2 mutation carriers is needed, especially in the field of cardio-oncology, requiring additional attention to potentially cumulative effects on cardiovascular risks in this specific group of women. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 171

页数：13

共 173 条

[81] Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age [J].

Lloyd-Jones, DM ;

Leip, EP ;

Larson, MG ;

D'Agostino, RB ;

Beiser, A ;

Wilson, PWF ;

Wolf, PA ;

Levy, D .

CIRCULATION, 2006, 113 (06) :791-798

[82] Increased visceral fat and decreased energy expenditure during the menopausal transition [J].

Lovejoy, J. C. ;

Champagne, C. M. ;

de Jonge, L. ;

Xie, H. ;

Smith, S. R. .

INTERNATIONAL JOURNAL OF OBESITY, 2008, 32 (06) :949-958

[83] Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause [J].

Mack, WJ ;

Slater, CC ;

Xiang, M ;

Shoupe, D ;

Lobo, RA ;

Hodis, HN .

FERTILITY AND STERILITY, 2004, 82 (02) :391-397

[84] The impact of hormone replacement therapy on menopausal symptoms in younger high-risk women after prophylactic salpingo-oophorectomy [J].

Madalinska, Joanna B. ;

van Beurden, Marc ;

Bleiker, Eveline M. A. ;

Valdimarsdottir, Heiddis B. ;

Hollenstein, Judith ;

Massuger, Leon F. ;

Gaarenstroom, Katja N. ;

Mourits, Marian J. E. ;

Verheijen, Rene H. M. ;

van Dorst, Eleonora B. L. ;

van der Putten, Hans ;

van der Velden, Ko ;

Boonstra, Henk ;

Aaronson, Neil K. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (22) :3576-3582

[85] Potential Excess Mortality in BRCA1/2 Mutation Carriers beyond Breast, Ovarian, Prostate, and Pancreatic Cancers, and Melanoma [J].

Mai, Phuong L. ;

Chatterjee, Nilanjan ;

Hartge, Patricia ;

Tucker, Margaret ;

Brody, Lawrence ;

Struewing, Jeffery P. ;

Wacholder, Sholom .

PLOS ONE, 2009, 4 (03)

[86] Estrogen therapy and coronary-artery calcification [J].

Manson, JoAnn E. ;

Allison, Matthew A. ;

Rossouw, Jacques E. ;

Carr, J. Jeffrey ;

Langer, Robert D. ;

Hsia, Judith ;

Kuller, Lewis H. ;

Cochrane, Barbara B. ;

Hunt, Julie R. ;

Ludlam, Shari E. ;

Pettinger, Mary B. ;

Gass, Margery ;

Margolis, Karen L. ;

Nathan, Lauren ;

Ockene, Judith K. ;

Prentice, Ross L. ;

Robbins, John ;

Stefanick, Marcia L. ;

Rossouw, J. E. ;

Ludlam, S. ;

Cochrane, B. B. ;

Hunt, J. R. ;

Lund, B. ;

Prentice, R. ;

Carr, J. J. ;

O'Rourke, C. ;

Du, L. ;

Pillsbury, S. ;

Hightower, C. ;

Ellison, R. ;

Tan, J. ;

Wassertheil-Smoller, S. ;

Magnani, M. ;

Noble, D. H. ;

Dellicarpini, T. ;

Manson, J. E. ;

Bueche, M. ;

McGinnis, A. D. ;

Rybicki, F. J. ;

Assaf, A. R. ;

Sloane, G. ;

Phillips, L. S. ;

Butler, V. ;

Huber, M. ;

Vitali, J. ;

Hsia, J. ;

LeBrun, C. ;

Palm, R. ;

Embersit, D. ;

Whitlock, E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (25) :2591-2602

[87] Risk factors for cardiovascular disease in women with a history of pregnancy complicated by preeclampsia or intrauterine growth restriction [J].

Manten, Gwendolyn T. R. ;

Sikkema, Marko J. ;

Voorbij, Hieronymus A. M. ;

Visser, Gerard H. A. ;

Bruinse, Hein W. ;

Franx, Arie .

HYPERTENSION IN PREGNANCY, 2007, 26 (01) :39-50

[88] Long term hormone therapy for perimenopausal and postmenopausal women [J].

Marjoribanks, Jane ;

Farquhar, Cindy ;

Roberts, Helen ;

Lethaby, Anne .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (07)

[89] Changes in Cardiovascular Risk Factors by Hysterectomy Status With and Without Oophorectomy Study of Women's Health Across the Nation [J].

Matthews, Karen A. ;

Gibson, Carolyn J. ;

El Khoudary, Samar R. ;

Thurston, Rebecca C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (03) :191-200

[90] Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition? [J].

Matthews, Karen A. ;

Crawford, Sybil L. ;

Chae, Claudia U. ;

Everson-Rose, Susan A. ;

Sowers, Mary Fran ;

Sternfeld, Barbara ;

Sutton-Tyrrell, Kim .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (25) :2366-2373

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