BRCA1/2 mutation carriers are potentially at higher cardiovascular risk

被引：27

作者：

Arts-de Jong, M. ^{[1
]}

Maas, A. H. E. M. ^{[2
]}

Massuger, L. F. ^{[1
]}

Hoogerbrugge, N. ^{[3
]}

de Hullu, J. A. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynecol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2014年 / 91卷 / 02期

关键词：

BRCA mutation; Cardiovascular disease; Risk-reducing salpingo-oophorectomy; Menopause; Cardio-oncology; INTIMA-MEDIA THICKNESS; HORMONE REPLACEMENT THERAPY; CORONARY-HEART-DISEASE; REDUCING SALPINGO-OOPHORECTOMY; EARLY BREAST-CANCER; PRIMARY OVARIAN INSUFFICIENCY; EARLY ESTROGEN PREVENTION; VASOMOTOR SYMPTOMS; WOMENS HEALTH; SUBCLINICAL ATHEROSCLEROSIS;

D O I：

10.1016/j.critrevonc.2014.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRCAI/2 mutation carriers have an elevated risk of developing breast and ovarian cancer at a relatively young age. Risk-reducing salpingooophorectomy is an established strategy to tremendously reduce the risk of ovarian cancer. It is recommended to perform this surgery at age 35-40 years (BRCA1) and at age 40-45 years (BRCA2) resulting in an early and abrupt menopause. BRCA1/2 mutation carriers are potentially at higher risk of cardiovascular diseases due to early surgical menopause, and cardiotoxic effects of adjuvant treatment for breast cancer. Furthermore, preliminary results of experimental studies suggest a possible causative function of the BRCA genes in cardiovascular risk. More research on cardiovascular health risks in BRCA1/2 mutation carriers is needed, especially in the field of cardio-oncology, requiring additional attention to potentially cumulative effects on cardiovascular risks in this specific group of women. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 171

页数：13

共 173 条

[41] Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials [J].

Darby S. ;

McGale P. ;

Correa C. ;

Taylor C. ;

Arriagada R. ;

Clarke M. ;

Cutter D. ;

Davies C. ;

Ewertz M. ;

Godwin J. ;

Gray R. ;

Pierce L. ;

Whelan T. ;

Wang Y. ;

Peto R. ;

Albain K. ;

Anderson S. ;

Barlow W. ;

Bergh J. ;

Bliss J. ;

Buyse M. ;

Cameron D. ;

Carrasco E. ;

Coates A. ;

Collins R. ;

Costantino J. ;

Cuzick J. ;

Davidson N. ;

Davies K. ;

Delmestri A. ;

Di Leo A. ;

Dowsett M. ;

Elphinstone P. ;

Evans V. ;

Gelber R. ;

Gettins L. ;

Geyer C. ;

Goldhirsch A. ;

Gregory C. ;

Hayes D. ;

Hill C. ;

Ingle J. ;

Jakesz R. ;

James S. ;

Kaufmann M. ;

Kerr A. ;

MacKinnon E. ;

McHugh T. ;

Norton L. ;

Ohashi Y. .

LANCET, 2011, 378 (9804) :1707-1716

[42]

EASTON DF, 1993, AM J HUM GENET, V52, P678

[43] Progression rates of carotid intima-media thickness and adventitial diameter during the menopausal transition [J].

El Khoudary, Samar R. ;

Wildman, Rachel P. ;

Matthews, Karen ;

Thurston, Rebecca C. ;

Bromberger, Joyce T. ;

Sutton-Tyrrell, Kim .

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2013, 20 (01) :8-14

[44] Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancers [J].

Evans, D. G. ;

Gaarenstroom, K. N. ;

Stirling, D. ;

Shenton, A. ;

Maehle, L. ;

Dorum, A. ;

Steel, M. ;

Lalloo, F. ;

Apold, J. ;

Porteous, M. E. ;

Vasen, H. F. A. ;

van Asperen, C. J. ;

Moller, P. .

JOURNAL OF MEDICAL GENETICS, 2009, 46 (09) :593-597

[45] Uptake of Risk-Reducing Surgery in Unaffected Women at High Risk of Breast and Ovarian Cancer Is Risk, Age, and Time Dependent [J].

Evans, D. Gareth R. ;

Lalloo, Fiona ;

Ashcroft, Linda ;

Shenton, Andrew ;

Clancy, Tara ;

Baildam, Andrew D. ;

Brain, Anne ;

Hopwood, Penelope ;

Howell, Anthony .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (08) :2318-2324

[46] The impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual function in women who carry a BRCA mutation [J].

Finch, A. ;

Metcalfe, K. A. ;

Chiang, J. K. ;

Elit, L. ;

McLaughlin, J. ;

Springate, C. ;

Demsky, R. ;

Murphy, J. ;

Rosen, B. ;

Narod, S. A. .

GYNECOLOGIC ONCOLOGY, 2011, 121 (01) :163-168

[47] Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation [J].

Finch, Amy ;

Valentini, Adriana ;

Greenblatt, Ellen ;

Lynch, Henry T. ;

Ghadirian, Parviz ;

Armel, Susan ;

Neuhausen, Susan L. ;

Kim-Sing, Charmaine ;

Tung, Nadine ;

Karlan, Beth ;

Foulkes, William D. ;

Sun, Ping ;

Narod, Steven .

FERTILITY AND STERILITY, 2013, 99 (06) :1724-1728

[48]

Finch A, 2012, WOMENS HEALTH, V8, P543, DOI [10.2217/WHE.12.41, 10.2217/whe.12.41]

[49] Longitudinal changes in abdominal fat distribution with menopause [J].

Franklin, Ruth M. ;

Ploutz-Snyder, Lori ;

Kanaley, Jill A. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2009, 58 (03) :311-315

[50] Menopausal complaints are associated with cardiovascular risk factors [J].

Gast, Gerrie-Cor M. ;

Grobbee, Diederick E. ;

Pop, Victor J. M. ;

Keyzer, Jules J. ;

Wijnands-van Gent, Colette J. M. ;

Samsioe, Goran N. ;

Nilsson, Peter M. ;

van der Schouw, Yvonne T. .

HYPERTENSION, 2008, 51 (06) :1492-1498

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