BRCA1/2 mutation carriers are potentially at higher cardiovascular risk

被引：27

作者：

Arts-de Jong, M. ^{[1
]}

Maas, A. H. E. M. ^{[2
]}

Massuger, L. F. ^{[1
]}

Hoogerbrugge, N. ^{[3
]}

de Hullu, J. A. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynecol, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2014年 / 91卷 / 02期

关键词：

BRCA mutation; Cardiovascular disease; Risk-reducing salpingo-oophorectomy; Menopause; Cardio-oncology; INTIMA-MEDIA THICKNESS; HORMONE REPLACEMENT THERAPY; CORONARY-HEART-DISEASE; REDUCING SALPINGO-OOPHORECTOMY; EARLY BREAST-CANCER; PRIMARY OVARIAN INSUFFICIENCY; EARLY ESTROGEN PREVENTION; VASOMOTOR SYMPTOMS; WOMENS HEALTH; SUBCLINICAL ATHEROSCLEROSIS;

D O I：

10.1016/j.critrevonc.2014.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRCAI/2 mutation carriers have an elevated risk of developing breast and ovarian cancer at a relatively young age. Risk-reducing salpingooophorectomy is an established strategy to tremendously reduce the risk of ovarian cancer. It is recommended to perform this surgery at age 35-40 years (BRCA1) and at age 40-45 years (BRCA2) resulting in an early and abrupt menopause. BRCA1/2 mutation carriers are potentially at higher risk of cardiovascular diseases due to early surgical menopause, and cardiotoxic effects of adjuvant treatment for breast cancer. Furthermore, preliminary results of experimental studies suggest a possible causative function of the BRCA genes in cardiovascular risk. More research on cardiovascular health risks in BRCA1/2 mutation carriers is needed, especially in the field of cardio-oncology, requiring additional attention to potentially cumulative effects on cardiovascular risks in this specific group of women. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 171

页数：13

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