Paucity of Plasmodium vivax Mature Schizonts in Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential

被引：48

作者：

Lopes, Stefanie C. P. ^{[1
,2
]}

Albrecht, Letusa ^{[1
]}

Carvalho, Bruna O. ^{[1
]}

Siqueira, Andre M. ^{[2
,3
]}

Thomson-Luque, Richard ^{[2
,4
]}

Nogueira, Paulo A. ^{[5
]}

Fernandez-Becerra, Carmen ^{[4
]}

del Portillo, Hernando A. ^{[4
,6
]}

Russell, Bruce M. ^{[7
,8
]}

Renia, Laurent ^{[7
]}

Lacerda, Marcus V. G. ^{[2
,3
]}

Costa, Fabio T. M. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Dept Genet Evolucao & Bioagentes, Inst Biol, Campinas, SP, Brazil

[2] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil

[3] Univ Estado Amazonas, Manaus, Amazonas, Brazil

[4] CRESIB, Barcelona Ctr Int Hlth Res, Barcelona, Spain

[5] Fiocruz MS, Inst Leonidas & Maria Deane, Manaus, Amazonas, Brazil

[6] ICREA, Barcelona, Spain

[7] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore, Singapore

[8] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Singapore 117595, Singapore

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

malaria; Plasmodium vivax; schizonts; disproportionality; cytoadhesion; sequestration; MALARIA;

D O I：

10.1093/infdis/jiu018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration.

引用

页码：1403 / 1407

页数：5

共 14 条

[1]

Baas C. C., 1921, American Journal of Tropical Medicine, V1, P29

[2] Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor [J].

Bernabeu, M. ;

Lopez, F. J. ;

Ferrer, M. ;

Martin-Jaular, L. ;

Razaname, A. ;

Corradin, G. ;

Maier, A. G. ;

del Portillo, H. A. ;

Fernandez-Becerra, C. .

CELLULAR MICROBIOLOGY, 2012, 14 (03) :386-400

[3] On the Cytoadhesion of Plasmodium vivax-Infected Erythrocytes [J].

Carvalho, Bruna O. ;

Lopes, Stefanie C. P. ;

Nogueira, Paulo A. ;

Orlandi, Patricia P. ;

Bargieri, Daniel Y. ;

Blanco, Yara C. ;

Mamoni, Ronei ;

Leite, Juliana A. ;

Rodrigues, Mauricio M. ;

Soares, Irene S. ;

Oliveira, Tatiane R. ;

Wunderlich, Gerhard ;

Lacerda, Marcus V. G. ;

del Portillo, Hernando A. ;

Araujo, Maria O. G. ;

Russell, Bruce ;

Suwanarusk, Rossarin ;

Snounou, Georges ;

Renia, Laurent ;

Costa, Fabio T. M. .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (04) :638-647

[4] Plasmodium vivax Adherence to Placental Glycosaminoglycans [J].

Chotivanich, Kesinee ;

Udomsangpetch, Rachanee ;

Suwanarusk, Rossarin ;

Pukrittayakamee, Sasithon ;

Wilairatana, Polrat ;

Beeson, James G. ;

Day, Nicholas P. J. ;

White, Nicholas J. .

PLOS ONE, 2012, 7 (04)

[5]

Field JW, 1963, STUDIES I MED RES FE, P108

[6] A Long Neglected World Malaria Map: Plasmodium vivax Endemicity in 2010 [J].

Gething, Peter W. ;

Elyazar, Iqbal R. F. ;

Moyes, Catherine L. ;

Smith, David L. ;

Battle, Katherine E. ;

Guerra, Carlos A. ;

Patil, Anand P. ;

Tatem, Andrew J. ;

Howes, Rosalind E. ;

Myers, Monica F. ;

George, Dylan B. ;

Horby, Peter ;

Wertheim, Heiman F. L. ;

Price, Ric N. ;

Mueeller, Ivo ;

Baird, Kevin ;

Hay, Simon I. .

PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (09)

[7]

Hingst HE, 1938, AM J TROP MED HYG S, Vs1-18, P361

[8] A new computational approach redefines the subtelomeric vir superfamily of Plasmodium vivax [J].

Javier Lopez, Francisco ;

Bernabeu, Maria ;

Fernandez-Becerra, Carmen ;

del Portillo, Hernando A. .

BMC GENOMICS, 2013, 14

[9] Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill? [J].

Lacerda, Marcus V. G. ;

Fragoso, Silvio C. P. ;

Alecrim, Maria G. C. ;

Alexandre, Mrcia A. A. ;

Magalhaes, Belisa M. L. ;

Siqueira, Andre M. ;

Ferreira, Luiz C. L. ;

Araujo, Jose R. ;

Mourao, Maria Paula G. ;

Ferrer, Mireia ;

Castillo, Paola ;

Martin-Jaular, Lorena ;

Fernandez-Becerra, Carmen ;

del Portillo, Hernando ;

Ordi, Jaume ;

Alonso, Pedro L. ;

Bassat, Quique .

CLINICAL INFECTIOUS DISEASES, 2012, 55 (08) :E67-E74

[10] Spleen Rupture in a Case of Untreated Plasmodium vivax Infection [J].

Machado Siqueira, Andre ;

Lopes Magalhaes, Belisa Maria ;

Cardoso Melo, Gisely ;

Ferrer, Mireia ;

Castillo, Paola ;

Martin-Jaular, Lorena ;

Fernandez-Becerra, Carmen ;

Ordi, Jaume ;

Martinez, Antonio ;

Guimaraes Lacerda, Marcus Vinicius ;

del Portillo, Hernando A. .

PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (12)

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