Immune checkpoints A therapeutic target in triple negative breast cancer

被引：36

作者：

Chawla, Akhil ^{[1
]}

Philips, Anne V. ^{[1
]}

Alatrash, Gheath ^{[2
]}

Mittendorf, Elizabeth ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplant & Cellular Therapy, Houston, TX 77030 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 04期

关键词：

PD-L1; PI3K; triple negative breast cancer; biomarker; immunotherapy; IMMUNOTHERAPY; ANTIBODY; SAFETY;

D O I：

10.4161/onci.28325

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Early clinical trials investigating monoclonal antibodies targeting the T-cell inhibitory receptor programmed cell death 1 (PD-1) and its ligand PD-L1 have shown efficacy in melanoma, non-small cell lung cancer and renal cell carcinoma. We recently demonstrated PD-L1 expression in 20% of triple negative breast cancers suggesting that targeting the PD-1/PD-L1 immune checkpoint may be an effective treatment modality in patients with this disease.

引用

页数：3

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