Serum antibodies against Panton-Valentine leukocidin in a normal population and during Staphylococcus aureus infection

被引：33

作者：

Croze, M. ^{[1
]}

Dauwalder, O. ^{[1
]}

Dumitrescu, O. ^{[1
]}

Badiou, C. ^{[1
]}

Gillet, Y. ^{[2
]}

Genestier, A. -L. ^{[1
]}

Vandenesch, F. ^{[1
]}

Etienne, J. ^{[1
]}

Lina, G. ^{[1
]}

机构：

[1] Univ Lyon 1, Ctr Natl Reference Staphylocoques, INSERM, U851,IFR Laennec 128, F-69372 Lyon 08, France

[2] Hop Edouard Herriot, Serv Urgences & Reanimat Pediat, Lyon, France

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2009年 / 15卷 / 02期

关键词：

Antibody; human; infection; Panton-Valentine leukocidin; Staphylococcus aureus;

D O I：

10.1111/j.1469-0691.2008.02650.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

To determine whether Staphylococcus aureus Panton-Valentine leukocidin (PVL) is expressed during human infection, anti-PVL antibody titres were compared in patients with PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection. These results indicate that only PVL-positive S. aureus strains elicit significant anti-PVL antibody production in humans, and demonstrate the production of PVL during PVL-positive S. aureus infection. The protective role of this immune response remains to be established.

引用

页码：144 / 148

页数：5

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