Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program

被引：5

作者：

Garcia, Sainza ^{[1
,2
,3
,4
]}

Gorostegi-Anduaga, Ilargi ^{[5
,6
]}

Garcia-Corres, Edurne ^{[1
,2
,4
]}

Maldonado-Martin, Sara ^{[5
,6
]}

MacDowell, Karina S. ^{[3
,7
]}

Bermudez-Ampudia, Cristina ^{[8
]}

Apodaca, Maria J. ^{[9
]}

Perez-Landaluce, Irene ^{[10
]}

Tobalina-Larrea, Ignacio ^{[4
,11
]}

Leza, Juan C. ^{[3
,7
]}

Gonzalez-Pinto, A. ^{[1
,2
,3
,4
]}

机构：

[1] Bioaraba Hlth Res Inst, Severe Mental Illness Res Grp, Vitoria, Spain

[2] Araba Univ Hosp, Osakdietza Basque Hlth Serv, Dept Psychiat, Vitoria, Spain

[3] Ctr Biomed Res Network Mental Hlth CIBERSAM, Madrid, Spain

[4] Univ Basque Country UPV EHU, Sch Med, Vitoria, Spain

[5] Univ Basque Country UPV EHU, Fac Educ & Sport, Dept Phys Educ & Sport, Vitoria, Spain

[6] Univ Basque Country UPV EHU, Soc Sports & Phys Exercise Res Grp, GIzartea Kirola & Ariketa Fisikoa Ikerkuntza Taid, Vitoria, Spain

[7] Univ Complutense Madrid, Dept Pharmacol & Toxicol, Fac Med, Madrid, Spain

[8] Bioaraba Hlth Res Inst, Epidemiol & Publ Hlth Res Grp, Vitoria, Spain

[9] Araba Univ Hosp, Osakdietza Basque Hlth Serv, Dept Cardiol, Vitoria, Spain

[10] Araba Univ Hosp, Osakdietza Basque Hlth Serv, Dept Ophthalmol, Vitoria, Spain

[11] Araba Univ Hosp, Osakdietza Basque Hlth Serv, Dept Nucl Med, Vitoria, Spain

来源：

FRONTIERS IN PSYCHIATRY | 2020年 / 11卷

关键词：

bipolar disorder; physical exercise; intervention program; neurocognition; functional capacity; LAYER STRUCTURE ABNORMALITIES; OPTICAL COHERENCE TOMOGRAPHY; MAJOR DEPRESSION; NEUROTROPHIC FACTOR; RATING-SCALE; SCHIZOPHRENIA; DYSFUNCTION; SYMPTOMS; BRAIN; METAANALYSIS;

D O I：

10.3389/fpsyt.2020.568455

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Introduction: Recent studies have shown that symptoms of psychiatric illness, functionality, and cognitive function improve with exercise. The aim of this study will be to investigate whether the implementation of an individualized exercise program will improve the functional status of patients with bipolar disorder (BD). Methods: This longitudinal, interventional, randomized, controlled, simple-blind clinical trial will include 80 patients aged 18-65 years, all of them with BD diagnosis. Patients will be randomly assigned to a physical exercise intervention + Treatment-As-Usual (TAU) group and a non-intervention + TAU group. Patients will be assessed by an extensive battery of clinical tests, physical parameters (e.g., brain structure changes measured by optical coherence tomography, cardiorespiratory fitness) and biological parameters (inflammation, oxidative stress and neurotrophic factors) at baseline, after a 4-month intervention period, and 6-month follow-up. Discussion: This is an innovative study aimed at gaining a deeper understanding of the physiopathology of BD and determining whether the prognosis and evolution of the disease can be improved through modifiable areas of the patient's lifestyle.

引用

页数：12

共 78 条

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