Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection

被引：38

作者：

Holder, Gerard E. ^{[1
]}

McGary, Christopher M. ^{[1
]}

Johnson, Edward M. ^{[1
]}

Zheng, Rubo ^{[2
]}

John, Vijay T. ^{[2
]}

Sugimoto, Chie ^{[3
]}

Kuroda, Marcelo J. ^{[3
]}

Kim, Woong-Ki ^{[1
]}

机构：

[1] Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VA 23507 USA

[2] Tulane Univ, Dept Chem & Biomed Engn, New Orleans, LA 70118 USA

[3] Tulane Natl Primate Res Ctr, Div Immunol, Covington, LA 70433 USA

来源：

JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2014年 / 9卷 / 05期

关键词：

AIDS; Bisphosphonate liposome; Bromodeoxyuridine; HIV encephalitis; Macrophage; CENTRAL-NERVOUS-SYSTEM; MENINGEAL MACROPHAGES; LOCAL PROLIFERATION; NONHUMAN PRIMATE; DOWN-REGULATION; IN-VIVO; MONOCYTES; ALENDRONATE; BLOOD; ATHEROSCLEROSIS;

D O I：

10.1007/s11481-014-9564-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206- shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this marker in studying the origin, turnover and functions of these cells in AIDS.

引用

页码：716 / 726

页数：11

共 19 条

[1] Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection
Gerard E. Holder
Christopher M. McGary
Edward M. Johnson
Rubo Zheng
Vijay T. John
Chie Sugimoto
Marcelo J. Kuroda
Woong-Ki Kim
Journal of Neuroimmune Pharmacology, 2014, 9 : 716 - 726
[2] Mannose receptor (CD206)-mediated signaling in human macrophages in the context of tuberculosis
Rajaram, Murugesan
Ni, Bin
Carlson, Tracy
Schlesinger, Larry
JOURNAL OF IMMUNOLOGY, 2014, 192
[3] The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease
Pamela B. Wright
Elizabeth McDonald
Alberto Bravo-Blas
Hannah M. Baer
Anna Heawood
Calum C. Bain
Allan M. Mowat
Slater L. Clay
Elaine V. Robertson
Fraser Morton
Jagtar Singh Nijjar
Umer Z. Ijaz
Simon W. F. Milling
Daniel R. Gaya
Scientific Reports, 11
[4] The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease
Wright, Pamela B.
McDonald, Elizabeth
Bravo-Blas, Alberto
Baer, Hannah M.
Heawood, Anna
Bain, Calum C.
Mowat, Allan M.
Clay, Slater L.
Robertson, Elaine V.
Morton, Fraser
Nijjar, Jagtar Singh
Ijaz, Umer Z.
Milling, Simon W. F.
Gaya, Daniel R.
SCIENTIFIC REPORTS, 2021, 11 (01)
[5] Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases
Wollenberg, A
Mommaas, M
Oppel, T
Schottdorf, EM
Günther, S
Moderer, M
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 118 (02) : 327 - 334
[6] Proliferation of perivascular macrophages in macaque models of lentiviral encephalitis: a potential mechanism for HIV/SIV persistence in the brain?
Filipowicz, Adam R.
McGary, Christopher M.
Holder, Gerard E.
Sugimoto, Chie
Kuroda, Marcelo J.
Kim, Woong-Ki
JOURNAL OF NEUROVIROLOGY, 2015, 21 : S22 - S22
[7] Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
Jaynes, Jesse M.
Sable, Rushikesh
Ronzetti, Michael
Bautista, Wendy
Knotts, Zachary
Abisoye-Ogunniyan, Abisola
Li, Dandan
Calvo, Raul
Dashnyam, Myagmarjav
Singh, Anju
Guerin, Theresa
White, Jason
Ravichandran, Sarangan
Kumar, Parimal
Talsania, Keyur
Chen, Vicky
Ghebremedhin, Anghesom
Karanam, Balasubramanyam
Bin Salam, Ahmad
Amin, Ruksana
Odzorig, Taivan
Aiken, Taylor
Nguyen, Victoria
Bian, Yansong
Zarif, Jelani C.
de Groot, Amber E.
Mehta, Monika
Fan, Lixin
Hu, Xin
Simeonov, Anton
Pate, Nathan
Abu-Asab, Mones
Ferrer, Marc
Southall, Noel
Ock, Chan-Young
Zhao, Yongmei
Lopez, Henry
Kozlov, Serguei
de Val, Natalia
Yates, Clayton C.
Baljinnyam, Bolormaa
Marugan, Juan
Rudloff, Udo
SCIENCE TRANSLATIONAL MEDICINE, 2020, 12 (530)
[8] Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain
Galea, I
Palin, K
Newman, TA
Van Rooijen, N
Perry, VH
Boche, D
GLIA, 2005, 49 (03) : 375 - 384
[9] Non-invasive visualization of atherosclerotic plaques using 68Ga-NOTA-anti-CD206-nanobody: targeting mannose receptor (MR, CD206) on M2 macrophages
Varasteh, Z.
Mohanta, S.
Li, Y.
Armbruster, N. Lopez
Braeuer, M.
Nekolla, S.
Habenicht, A.
Sager, H.
Raes, G.
Hernot, S.
Schwaiger, M.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 : S371 - S371
[10] Persisting Donor Alveolar Macrophages Have Increased Expression of Scavenger Receptor CD206 Compared to Graft-Infiltrating Recipient-Derived Macrophages Following Lung Transplantation
Snyder, M. E.
Weisberg, S. P.
Connors, T.
Benvenuto, L.
Shah, L.
Robbins, H. J.
Hook, J. L.
D'Ovidio, F.
Sonett, J.
Arcasoy, S.
Farber, D. L.
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2019, 38 (04): : S158 - S158

← 1 2 →