Racial disparity in survival of patients diagnosed with early-onset colorectal cancer

被引：4

作者：

Wallace, Kristin ^{[1
,2
]}

Li, Hong ^{[1
,2
]}

Paulos, Chrystal M. ^{[3
]}

Lewin, David N. ^{[4
]}

Alekseyenko, Alexander, V ^{[1
,5
,6
,7
]}

机构：

[1] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA

[3] Med Univ South Carolina, Dept Microbiol Immunol, Charleston, SC 29425 USA

[4] Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA

[5] Med Univ South Carolina, Biomed Informat Ctr, Coll Dent Med, Charleston, SC 29425 USA

[6] Med Univ South Carolina, Dept Oral Hlth Sci, Coll Dent Med, Charleston, SC 29425 USA

[7] Med Univ South Carolina, Coll Hlth Profess, Dept Healthcare Leadership & Management, Charleston, SC 29425 USA

来源：

COLORECTAL CANCER | 2020年 / 9卷 / 03期

关键词：

African-Americans; Caucasians; colon; colorectal cancer; early onset; mucinous; proximal colon; race; rectal; survival; treatment; LEFT-SIDED COLON; SOCIOECONOMIC-STATUS; AFRICAN-AMERICANS; MORTALITY; RATES; STAGE; RACE; METAANALYSIS; ASSOCIATION; NEOPLASIA;

D O I：

10.2217/crc-2020-0015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Survival is reduced in African-Americans (AAs) diagnosed with colorectal cancer (CRC), especially in those <50 years old, when compared with Caucasian Americans (CAs). Yet, the role of clinicopathologic features of CRCs on racial differences in survival needs further study. Materials & methods: Over 1000 individuals (CA 709, AA 320) diagnosed with CRC were studied for survival via the Cox proportional hazards regression analysis based on race and risk of death in two age groups (<50 or 50+). Results: Risk of death for younger AAs (<50) was elevated compared with younger CAs (hazard ratio [HR] 1.98 [1.26-3.09]). Yet no racial differences in survival was observed in older cohort (50+ years), HR 1.07 (0.88-1.31); p for interaction = 0.01. In younger AAs versus CAs only, colonic location attenuated the risk of death. Conclusion: The tumor location and histology influence the poorer survival observed in younger AAs suggesting these may also influence treatment responses.

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页数：9

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