Targeted Therapies in Non-Small Cell Lung Cancer: Emerging Oncogene Targets Following the Success of Epidermal Growth Factor Receptor

被引：56

作者：

Berge, Eamon M. ^{[1
]}

Doebele, Robert C. ^{[1
]}

机构：

[1] Univ Colorado, Div Med Oncol, Dept Med, Aurora, CO 80045 USA

来源：

SEMINARS IN ONCOLOGY | 2014年 / 41卷 / 01期

关键词：

RANDOMIZED PHASE-II; ANAPLASTIC LYMPHOMA KINASE; K-RAS ONCOGENE; ACQUIRED-RESISTANCE; GENE AMPLIFICATION; SOMATIC MUTATIONS; CLINICAL-FEATURES; SIGNALING PATHWAY; KRAS MUTATIONS; NEVER-SMOKERS;

D O I：

10.1053/j.seminoncol.2013.12.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The diagnostic testing, treatment and prognosis of non-small cell lung cancer (NSCLC) has undergone a paradigm shift since the discovery of sensitizing mutations in the epidermal growth factor receptor (EGFR) gene in a subset of NSCLC patients. Several additional oncogenic mutations, including gene fusions and amplifications, have since been discovered, with a number of drugs that target each specific oncogene. This review focuses on oncogenes in NSCLC other than EGFR and their companion "targeted therapies." Particular emphasis is placed on the role of ALK, ROS1, RET, MET, BRAF, and HER2 in NSCLC. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：110 / 125

页数：16

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