Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

被引：310

作者：

Yates, Clara M. ^{[1
]}

Calder, Philip C. ^{[2
]}

Rainger, G. Ed ^{[1
]}

机构：

[1] Univ Birmingham, Sch Clin & Expt Med, Ctr Cardiovasc Sci, Birmingham B15 2TT, W Midlands, England

[2] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO16 6YD, Hants, England

来源：

PHARMACOLOGY & THERAPEUTICS | 2014年 / 141卷 / 03期

关键词：

Omega-3 polyunsaturated fatty acid; Eicosapentaenoic acid; Docosahexaenoic acid; Inflammation; Eicosanoid; Resolvin; FISH-OIL SUPPLEMENTATION; TUMOR-NECROSIS-FACTOR; RANDOMIZED CONTROLLED-TRIAL; PROLIFERATOR-ACTIVATED RECEPTORS; CYTOKINE-INDUCED EXPRESSION; EUROPEAN PROSPECTIVE COHORT; PLACEBO-CONTROLLED TRIAL; ALPHA-LINOLENIC ACID; NF-KAPPA-B; DOCOSAHEXAENOIC ACID;

D O I：

10.1016/j.pharmthera.2013.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Omega-3 (n-3) polyunsaturated fatty acids (n-3 PUFAs) have well documented anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory diseases. Here we discuss the effects of n-3 PUFAs on various inflammatory pathways and how this leads to alterations in the function of inflammatory cells, most importantly endothelial cells and leukocytes. Strong evidence indicates n-3 PUFAs are beneficial as a dietary supplement in certain diseases such as rheumatoid arthritis; however for other conditions such as asthma, the data are less robust. A clearer understanding of the pharmacology of n-3 PUFAs will help to establish targets to modulate chronic inflammatory diseases. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：272 / 282

页数：11

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